TY  - JOUR
A1  - Meng, Li
A1  - Sendtner, Michael
A1  - Smith, Austin
T1  - Essential function of LIF receptor in motor neurons
N2  - D EVELOPME'iT and maintenance of the mammalian nervous system is dependent upon neurotrophic cytokines. One class of neurotrophic factor acts through rcccptor complexes involving the lowaffinity leukaemia inhibitor y faclor receptor subunit (LlF-R). Members of this fa mily of cytokines, such as ciliary neurotrophic factor (CNTF) and leukaemia inhibitory factor (LIF), have profound effects on the survival and maintenance of motor neurons, Recently it was reported that mice lacking LlF-R die shortly after birth unlike mice lacking CNTF or LIF which are viable. Here we describe histopathological analyses of lifr mutants tha t reveal a loss > 35% of facia l motor neurons, 40% of spinal motor neurons and 50% of neurons in the nucleus ambiguus. These findings point to the existence of a ligand for LIF-R tha t is required for the normal development of motor neurons in both brainstem nuclei and spinal cord.
Y1  - 1995
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/3078
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-34219
ER  -