TY  - JOUR
A1  - Werner, Rudolf A.
A1  - Ordonez, Alvaro A.
A1  - Sanchez-Bautista, Julian
A1  - Marcus, Charles
A1  - Lapa, Constantin
A1  - Rowe, Steven P.
A1  - Pomper, Martin G.
A1  - Leal, Jeffrey P.
A1  - Lodge, Martin A.
A1  - Javadi, Mehrbod S.
A1  - Jain, Sanjay K.
A1  - Higuchi, Takahiro
T1  - Novel functional renal PET imaging with 18F-FDS in human subjects
T2  - Clinical Nuclear Medicine
N2  - The novel PET probe 2-deoxy-2-18F-fluoro-D-sorbitol (18F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in two human volunteers. 18F-FDS was produced by a simple one-step reduction from 18F-FDG. On dynamic renal PET, the cortex was delineated and activity gradually transited in the parenchyma, followed by radiotracer excretion. No adverse effects were reported. Given the higher spatiotemporal resolution of PET relative to conventional scintigraphy, 18F-FDS PET offers a more thorough evaluation of human renal kinetics. Due to its simple production from 18F-FDG, 18F-FDS is virtually available at any PET facility with radiochemistry infrastructure.
KW  - 2-deoxy-2-18F-fluoro-D-sorbitol
KW  - Positronen-Emissions-Tomografie
KW  - 18F-FDS
KW  - renal imaging
KW  - Positron-Emission Tomography
KW  - split renal function
KW  - kidney
Y1  - 2019
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/17463
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-174634
SN  - 0363-9762
VL  - 44
IS  - 5
ER  -