TY  - JOUR
A1  - Scherzad, Agmal
A1  - Hagen, Rudolf
A1  - Hackenberg, Stephan
T1  - Current Understanding of Nasal Epithelial Cell Mis-Differentiation
T2  - Journal of Inflammation Research
N2  - The functional role of the respiratory epithelium is to generate a physical barrier. In addition, the epithelium supports the innate and acquired immune system through various cytokines and chemokines. However, epithelial cells are also involved in the pathogenesis of various respiratory diseases, some of which are mediated by increased permeability of the mucosal membrane or disturbed mucociliary transport. In addition, it has been shown that epithelial cells are involved in the development of inflammatory respiratory diseases. The following review article focuses on the aspects of epithelial mis-differentiation, in particular with respect to nasal mucosal barrier function, epithelial immunogenicity, nasal epithelial-mesenchymal transition and nasal microbiome.
KW  - nasal mucosal barrier function
KW  - tight junction
KW  - epithelial-mesenchymal transition
KW  - microbiome
Y1  - 2019
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/22856
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-228562
VL  - 12
ER  -