TY  - JOUR
A1  - Meier-Bratschi, A.
A1  - Lutz, Werner K.
A1  - Schlatter, C.
T1  - Methylation of liver DNA of rat and mouse by N-nitrosodimethylamine formed in vivo from dimethylamine and nitrite
N2  - The extent of formation of N-nitrosodimethylaminc {NDMA) in the stomachs of rats and mice after sirnultancous oral administration of [\(^{14}\)C]dimethylamine and potassium nitrite was determined by measuring the methylation of liver DNA. With doses of around 1 mg dimethylamine hydrochloride/ kg body weight and 50 mg potassium nitrite/kg body weight. 0,8 % of the amine was nitrosated on average. The individual fluctuations ranged from 0.2 to 1.30% in the rat and from 0.2 to 1.9% in the mouse. Simultaneous administration of 50 mg sodium ascorbate (vitamin Cl/kg body weight inhibited the nitrosation by ahout 80% while 50 mg \(\alpha\)-tocopherol acetate [Vitamin E)/kg body weight reduced the nitrosation by about a half. Assuming similar kinctics and conditions of nitrosation in rats and man. a comparison of the formation of NDMA in vivo from dietary dimethylamine and nitrite with the estimated human uptake of preformed N DMA revealed that in vitro formation in the stomach of man is probably negligible.
KW  - Toxikologie
Y1  - 1983
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/5483
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-61052
ER  -