TY  - JOUR
A1  - Link, Jana
A1  - Paouneskou, Dimitra
A1  - Velkova, Maria
A1  - Daryabeigi, Anahita
A1  - Laos, Triin
A1  - Labella, Sara
A1  - Barroso, Consuelo
A1  - Pacheco Piñol, Sarai
A1  - Montoya, Alex
A1  - Kramer, Holger
A1  - Woglar, Alexander
A1  - Baudrimont, Antoine
A1  - Markert, Sebastian Mathias
A1  - Stigloher, Christian
A1  - Martinez-Perez, Enrique
A1  - Dammermann, Alexander
A1  - Alsheimer, Manfred
A1  - Zetka, Monique
A1  - Jantsch, Verena
T1  - Transient and Partial Nuclear Lamina Disruption Promotes Chromosome Movement in Early Meiotic Prophase
T2  - Developmental Cell
N2  - Meiotic chromosome movement is important for the pairwise alignment of homologous chromosomes, which is required for correct chromosome segregation. Movement is driven by cytoplasmic forces, transmitted to chromosome ends by nuclear membrane-spanning proteins. In animal cells, lamins form a prominent scaffold at the nuclear periphery, yet the role lamins play in meiotic chromosome movement is unclear. We show that chromosome movement correlates with reduced lamin association with the nuclear rim, which requires lamin phosphorylation at sites analogous to those that open lamina network crosslinks in mitosis. Failure to remodel the lamina results in delayed meiotic entry, altered chromatin organization, unpaired or interlocked chromosomes, and slowed chromosome movement. The remodeling kinases are delivered to lamins via chromosome ends coupled to the nuclear envelope, potentially enabling crosstalk between the lamina and chromosomal events. Thus, opening the lamina network plays a role in modulating contacts between chromosomes and the nuclear periphery during meiosis.
KW  - meiosis
KW  - C. elegans
KW  - chromosome movement
KW  - chromosome pairing
KW  - nuclear envelope
KW  - lamin
Y1  - 2018
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/23690
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-236901
VL  - 45
ER  -