TY  - JOUR
A1  - Lutz, Werner K.
A1  - Schlatter, C.
T1  - In vivo covalent binding of chemicals to DNA as a short-term test for carcinogenicity
N2  - The determination of a covalent binding of radioactive chemieals to DNA in intact mammalian organisms is proposedas a short-term test for carcinogenicity. The effectiveness of covalent binding to rat liver DNA correlates well with the hepatocarcinogenicity known from long-term bioassays. The binding indices range over more than five orders of rriagnitude between the strongest hepatocarcinogen aflatoxin B 1 and the limit of detection of a binding with 100 f-LCi 14C-labelled chemical. The order of magnitude of binding is therefore a surprisingly good quantitative measure for carcinogenicity. The pattern of DNA binding sites is important especially for small alkylating agents where the determination of total binding might indicate a higher carcinogenic potency than is actually observed.
KW  - DNA
KW  - DNA-Binding
KW  - Carcinogen
KW  - Short-term Carcinogenicity Test
KW  - Aflatoxin
KW  - Toluene
KW  - Tritiated Water
Y1  - 1979
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/6814
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-80127
ER  -