TY  - JOUR
A1  - Kleinschnitz, Christoph
A1  - Göbel, Kerstin
A1  - Meuth, Sven G.
A1  - Kraft, Peter
T1  - Glatiramer acetate does not protect from acute ischemic stroke in mice
N2  - Background

The role of the immune system in the pathophysiology of acute ischemic stroke is increasingly recognized. However, targeted treatment strategies to modulate immunological pathways in stroke are still lacking. Glatiramer acetate is a multifaceted immunomodulator approved for the treatment of relapsing-remitting multiple sclerosis. Experimental studies suggest that glatiramer acetate might also work in other neuroinflammatory or neurodegenerative diseases apart from multiple sclerosis.

Findings

We evaluated the efficacy of glatiramer acetate in a mouse model of brain ischemia/reperfusion injury. 60 min of transient middle cerebral artery occlusion was induced in male C57Bl/6 mice. Pretreatment with glatiramer acetate (3.5 mg/kg bodyweight) 30 min before the induction of stroke did not reduce lesion volumes or improve functional outcome on day 1.

Conclusions

Glatiramer acetate failed to protect from acute ischemic stroke in our hands. Further studies are needed to assess the true therapeutic potential of glatiramer acetate and related immunomodulators in brain ischemia.
KW  - Glatiramer acetate
KW  - Stroke
KW  - Inflammation
KW  - Neurodegeneration
Y1  - 2014
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/11052
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-110528
ER  -