TY  - JOUR
A1  - Drakopoulos, Antonios
A1  - Decker, Michael
T1  - Development and Biological Applications of Fluorescent Opioid Ligands
T2  - ChemPlusChem
N2  - Opioid receptors (ORs) are classified among the oldest and best investigated drug targets due to their fundamental role in the treatment of pain and related disorders. ORs are divided in three conventional subtypes (μ, κ, δ) and the non‐classical nocicepetin receptor. All ORs are family A G protein‐coupled receptors (GPCRs), and are located on the cell surface. Modern biophysical methods use light to investigate physiological processes at organismal, cellular and subcellular level. Many of these methods rely on fluorescent ligands, thus highlighting their importance. This review addresses the advancements in the development of opioid fluorescent ligands and their use in biological, pharmacological and imaging applications.
KW  - biophysics
KW  - fluorescent ligands
KW  - imaging
KW  - microscopy
KW  - opioid receptors
Y1  - 2020
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/21606
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-216068
VL  - 85
IS  - 6
SP  - 1354
EP  - 1364
ER  -