TY  - JOUR
A1  - Frey, Anna
A1  - Gassenmaier, Tobias
A1  - Hofmann, Ulrich
A1  - Schmitt, Dominik
A1  - Fette, Georg
A1  - Marx, Almuth
A1  - Heterich, Sabine
A1  - Boivin-Jahns, Valérie
A1  - Ertl, Georg
A1  - Bley, Thorsten
A1  - Frantz, Stefan
A1  - Jahns, Roland
A1  - Störk, Stefan
T1  - Coagulation factor XIII activity predicts left ventricular remodelling after acute myocardial infarction
T2  - ESC Heart Failure
N2  - Aims Acute myocardial infarction (MI) is the major cause of chronic heart failure. The activity of blood coagulation factor XIII (FXIIIa) plays an important role in rodents as a healing factor after MI, whereas its role in healing and remodelling processes in humans remains unclear. We prospectively evaluated the relevance of FXIIIa after acute MI as a potential early prognostic marker for adequate healing.
Methods and results This monocentric prospective cohort study investigated cardiac remodelling in patients with ST-elevation MI and followed them up for 1 year. Serum FXIIIa was serially assessed during the first 9 days after MI and after 2, 6, and 12 months. Cardiac magnetic resonance imaging was performed within 4 days after MI (Scan 1), after 7 to 9 days (Scan 2), and after 12 months (Scan 3). The FXIII valine-to-leucine (V34L) single-nucleotide polymorphism rs5985 was genotyped. One hundred forty-six patients were investigated (mean age 58 ± 11 years, 13% women). Median FXIIIa was 118 % (quartiles, 102–132%) and dropped to a trough on the second day after MI: 109%(98–109%; P < 0.001). FXIIIa recovered slowly over time, reaching the baseline level after 2 to 6 months and surpassed baseline levels only after 12 months: 124 % (110–142%). The development of FXIIIa after MI was independent of the genotype. FXIIIa on Day 2 was strongly and inversely associated with the relative size of MI in Scan 1 (Spearman’s ρ = –0.31; P = 0.01) and Scan 3 (ρ = –0.39; P < 0.01) and positively associated with left ventricular ejection fraction: ρ = 0.32 (P < 0.01) and ρ = 0.24 (P = 0.04), respectively.
Conclusions FXIII activity after MI is highly dynamic, exhibiting a significant decline in the early healing period, with reconstitution 6 months later. Depressed FXIIIa early after MI predicted a greater size of MI and lower left ventricular ejection fraction after 1 year. The clinical relevance of these findings awaits to be tested in a randomized trial.
KW  - blood coagulation factor XIII
KW  - ST-elevation myocardial infarction
KW  - healing and remodelling processes
KW  - cardiac magnetic resonance imaging
Y1  - 2020
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/23601
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-236013
VL  - 7
IS  - 5
ER  -