TY  - JOUR
A1  - Angheloiu, George O.
A1  - Hänscheid, Heribert
A1  - Wen, Xiaoyan
A1  - Capponi, Vincent
A1  - Anderson, William D.
A1  - Kellum, John A.
T1  - Experimental first-pass method for testing and comparing sorbent polymers used in the clearance of iodine contrast materials
T2  - Blood Purification
N2  - Background: Sorbents have been shown to adsorb iodinated radiocontrast media. Objective: In this study we describe a simple method to compare various sorbents in terms of capacity to adsorb radiocontrast media. Methods: Iodixanol solution was injected into columns filled with three types of sorbent at filtration velocities of increasing magnitude. Two variables of interest – contrast removal rate and matched iodine retention (MIR) – were calculated to measure the adsorption efficiency and the mass of contrast iodine adsorbed versus sorbent used, respectively. Results: The highest contrast removal and MIR for Porapak Q, CST 401 and Amberlite XAD4 were 41, 38 and 16% (p = 0.22 and 0.0005 for comparisons between Porapak Q-CST 401 and CST 401-Amberlite XAD4) and 0.060, 0.055 and 0.024, respectively (p = 0.18 and 0.0008). Extrapolation to a clinical scenario may suggest that removal of 8 ml iodixanol could be achieved by masses of sorbents of 43, 47 and 107 g, respectively. Conclusion: In this study we set a benchmark for comparing the radiocontrast-adsorbing efficiency of polymer sorbents during first-pass experiments, using a readily available methodology.
KW  - adsorption
KW  - acute renal failure
KW  - sorbents
KW  - iodine contrast
Y1  - 2012
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/19911
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-199118
SN  - 0253-5068
SN  - 1421-9735
N1  - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
VL  - 34
IS  - 1
ER  -