TY  - JOUR
A1  - Gutiérrez, Gustavo
A1  - Giraldo-Dávila, Deisy
A1  - Combariza, Marianny Y.
A1  - Holzgrabe, Ulrike
A1  - Tabares-Guevara, Jorge Humberto
A1  - Ramírez-Pineda, José Robinson
A1  - Acín, Sergio
A1  - Muñoz, Diana Lorena
A1  - Montoya, Guillermo
A1  - Balcazar, Norman
T1  - Serjanic acid improves immunometabolic markers in a diet-induced obesity mouse model
T2  - Molecules
N2  - Plant extracts from Cecropia genus have been used by Latin-American traditional medicine to treat metabolic disorders and diabetes. Previous reports have shown that roots of Cecropia telenitida that contains serjanic acid as one of the most prominent and representative pentacyclic triterpenes. The study aimed to isolate serjanic acid and evaluate its effect in a prediabetic murine model by oral administration. A semi-pilot scale extraction was established and serjanic acid purification was followed using direct MALDI-TOF analysis. A diet induced obesity mouse model was used to determine the impact of serjanic acid over selected immunometabolic markers. Mice treated with serjanic acid showed decreased levels of cholesterol and triacylglycerols, increased blood insulin levels, decreased fasting blood glucose and improved glucose tolerance, and insulin sensitivity. At transcriptional level, the reduction of inflammation markers related to adipocyte differentiation is reported.
KW  - Cecropia telenitida
KW  - serjanic acid
KW  - type 2 diabetes
Y1  - 2020
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/20325
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-203253
SN  - 1420-3049
VL  - 25
IS  - 7
ER  -