TY  - JOUR
A1  - Apsemidou, Athanasia
A1  - Füller, Miriam Antonie
A1  - Idelevich, Evgeny A.
A1  - Kurzai, Oliver
A1  - Tragiannidis, Athanasios
A1  - Groll, Andreas H.
T1  - Candida lusitaniae breakthrough fungemia in an immuno-compromised adolescent: case report and review of the literature
T2  - Journal of Fungi
N2  - Candida lusitaniae is a rare cause of candidemia that is known for its unique capability to rapidly acquire resistance to amphotericin B. We report the case of an adolescent with grade IV graft-vs.-host disease after hematopoietic cell transplantation who developed catheter-associated C. lusitaniae candidemia while on therapeutic doses of liposomal amphotericin B. We review the epidemiology of C. lusitaniae bloodstream infections in adult and pediatric patients, the development of resistance, and its role in breakthrough candidemia. Appropriate species identification, in vitro susceptibility testing, and source control are pivotal to optimal management of C. lusitaniae candidemia. Initial antifungal therapy may consist of an echinocandin and be guided by in vitro susceptibility and clinical response.
KW  - Candida lusitaniae
KW  - candidemia
KW  - resistance
KW  - breakthrough
KW  - infection
KW  - transplantation
Y1  - 2020
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/22012
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-220125
SN  - 2309-608X
VL  - 6
IS  - 4
ER  -