TY  - JOUR
A1  - Heilig, Philipp
A1  - Sandner, Phoebe
A1  - Jordan, Martin Cornelius
A1  - Jakubietz, Rafael Gregor
A1  - Meffert, Rainer Heribert
A1  - Gbureck, Uwe
A1  - Hoelscher-Doht, Stefanie
T1  - Experimental drillable magnesium phosphate cement is a promising alternative to conventional bone cements
T2  - Materials
N2  - Clinically used mineral bone cements lack high strength values, absorbability and drillability. Therefore, magnesium phosphate cements have recently received increasing attention as they unify a high mechanical performance with presumed degradation in vivo. To obtain a drillable cement formulation, farringtonite (Mg\(_3\)(PO\(_4\))\(_2\)) and magnesium oxide (MgO) were modified with the setting retardant phytic acid (C\(_6\)H\(_{18}\)O\(_{24}\)P\(_6\)). In a pre-testing series, 13 different compositions of magnesium phosphate cements were analyzed concentrating on the clinical demands for application. Of these 13 composites, two cement formulations with different phytic acid content (22.5 wt% and 25 wt%) were identified to meet clinical demands. Both formulations were evaluated in terms of setting time, injectability, compressive strength, screw pullout tests and biomechanical tests in a clinically relevant fracture model. The cements were used as bone filler of a metaphyseal bone defect alone, and in combination with screws drilled through the cement. Both formulations achieved a setting time of 5 min 30 s and an injectability of 100%. Compressive strength was shown to be ~12–13 MPa and the overall displacement of the reduced fracture was <2 mm with and without screws. Maximum load until reduced fracture failure was ~2600 N for the cements only and ~3800 N for the combination with screws. Two new compositions of magnesium phosphate cements revealed high strength in clinically relevant biomechanical test set-ups and add clinically desired characteristics to its strength such as injectability and drillability.
KW  - magnesium phosphate cement
KW  - phytic acid
KW  - inositol hexaphosphate
KW  - drillable bone cement
KW  - tibial head depression fracture
KW  - synbones
KW  - artificial bones
KW  - biomechanical evaluation
KW  - cyclic testing
KW  - load to failure testing
Y1  - 2021
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/23663
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-236633
SN  - 1996-1944
VL  - 14
IS  - 8
ER  -