TY  - JOUR
A1  - Meintrup, David
A1  - Borgmann, Stefan
A1  - Seidl, Karlheinz
A1  - Stecher, Melanie
A1  - Jakob, Carolin E. M.
A1  - Pilgram, Lisa
A1  - Spinner, Christoph D.
A1  - Rieg, Siegbert
A1  - Isberner, Nora
A1  - Hower, Martin
A1  - Vehreschild, Maria
A1  - Göpel, Siri
A1  - Hanses, Frank
A1  - Nowak-Machen, Martina
T1  - Specific risk factors for fatal outcome in critically ill COVID-19 patients: results from a European multicenter study
T2  - Journal of Clinical Medicine
N2  - (1) Background: The aim of our study was to identify specific risk factors for fatal outcome in critically ill COVID-19 patients. (2) Methods: Our data set consisted of 840 patients enclosed in the LEOSS registry. Using lasso regression for variable selection, a multifactorial logistic regression model was fitted to the response variable survival. Specific risk factors and their odds ratios were derived. A nomogram was developed as a graphical representation of the model. (3) Results: 14 variables were identified as independent factors contributing to the risk of death for critically ill COVID-19 patients: age (OR 1.08, CI 1.06–1.10), cardiovascular disease (OR 1.64, CI 1.06–2.55), pulmonary disease (OR 1.87, CI 1.16–3.03), baseline Statin treatment (0.54, CI 0.33–0.87), oxygen saturation (unit = 1%, OR 0.94, CI 0.92–0.96), leukocytes (unit 1000/μL, OR 1.04, CI 1.01–1.07), lymphocytes (unit 100/μL, OR 0.96, CI 0.94–0.99), platelets (unit 100,000/μL, OR 0.70, CI 0.62–0.80), procalcitonin (unit ng/mL, OR 1.11, CI 1.05–1.18), kidney failure (OR 1.68, CI 1.05–2.70), congestive heart failure (OR 2.62, CI 1.11–6.21), severe liver failure (OR 4.93, CI 1.94–12.52), and a quick SOFA score of 3 (OR 1.78, CI 1.14–2.78). The nomogram graphically displays the importance of these 14 factors for mortality. (4) Conclusions: There are risk factors that are specific to the subpopulation of critically ill COVID-19 patients.
KW  - COVID-19
KW  - SARS-CoV-2
KW  - risk factors
KW  - critically ill patients
KW  - comorbidities
KW  - lasso regression
KW  - nomogram
Y1  - 2021
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/24519
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-245191
SN  - 2077-0383
VL  - 10
IS  - 17
ER  -