TY  - JOUR
A1  - Strunz, Patrick-Pascal
A1  - Froehlich, Matthias
A1  - Gernert, Michael
A1  - Schwaneck, Eva Christina
A1  - Fleischer, Anna
A1  - Pecher, Ann-Christin
A1  - Tony, Hans-Peter
A1  - Henes, Joerg Christoph
A1  - Schmalzing, Marc
T1  - Immunological Adverse Events After Autologous Hematopoietic Stem Cell Transplantation in Systemic Sclerosis Patients
T2  - Frontiers in Immunology
N2  - Autologous hematopoietic stem cell transplantation (aHSCT) represents an effective treatment for systemic sclerosis (SSc), but it also can cause immunological adverse events (iAEs). Therefore, we aimed to determine the frequency of iAEs [engraftment syndrome (ES) and secondary autoimmune disorder (sAD)] and to identify potential risk factors for their development in a retrospective analysis on 22 patients similarly transplanted due to SSc. While nine patients (41%) suffered from ESs, seven sADs occurred in six patients (27%). Patients who developed ES were older in our cohort (52.45 vs. 42.58 years, p = .0433, Cohen’s d = 0.86), and cardiac involvement by SSc was associated with development of ES (OR = 40.11, p = .0017). Patients with manifestation of sAD had a higher modified Rodnan skin score (mRSS) reduction after aHSCT (90.50% vs. 60.00%, p = .0064, r = .65). Thus, IAEs are common after aHSCT for SSc and can occur in different stages during and after aHSCT with characteristic clinical manifestations. Good cutaneous response after aHSCT might be considered as a risk factor for sAD, and higher age at aHSCT and cardiac involvement might be considered as risk factors for the development of ES.
KW  - scleroderma
KW  - fever
KW  - autoimmune disease
KW  - Grave’s disease
KW  - modified Rodnan skin score (mRSS)
KW  - risk factor analysis
KW  - engraftment syndrome
KW  - Sjögren’s syndrome
Y1  - 2021
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/24557
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-245574
SN  - 1664-3224
VL  - 12
ER  -