TY  - JOUR
A1  - Lippert, Juliane
A1  - Fassnacht, Martin
A1  - Ronchi, Cristina L.
T1  - The role of molecular profiling in adrenocortical carcinoma
T2  - Clinical Endocrinology
N2  - Adrenocortical carcinoma (ACC) is a rare, aggressive cancer with still partially unknown pathogenesis, heterogenous clinical behaviour and no effective treatment for advanced stages. Therefore, there is an urgent clinical unmet need for better prognostication strategies, innovative therapies and significant improvement of the management of the individual patients. In this review, we summarize available studies on molecular prognostic markers and markers predictive of response to standard therapies as well as newly proposed drug targets in sporadic ACC. We include in vitro studies and available clinical trials, focusing on alterations at the DNA, RNA and epigenetic levels. We also discuss the potential of biomarkers to be implemented in a clinical routine workflow for improved ACC patient care.
KW  - adrenocortical cancer
KW  - biomarkers
KW  - precision medicine
KW  - prognosis
KW  - targeted treatment
Y1  - 2022
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/25838
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-258382
VL  - 97
IS  - 4
ER  -