TY  - JOUR
A1  - Gágyor, Ildikó
A1  - Greser, Alexandra
A1  - Heuschmann, Peter
A1  - Rücker, Viktoria
A1  - Maun, Andy
A1  - Bleidorn, Jutta
A1  - Heintze, Christoph
A1  - Jede, Felix
A1  - Eckmanns, Tim
A1  - Klingeberg, Anja
A1  - Mentzel, Anja
A1  - Schiemann, Guido
T1  - REDuction of Antibiotic RESistance (REDARES) in urinary tract infections using treatments according to national clinical guidelines: study protocol for a pragmatic randomized controlled trial with a multimodal intervention in primary care
T2  - BMC Infectious Diseases
N2  - Background: Urinary tract infections (UTIs) are a common cause of prescribing antibiotics in family medicine. In Germany, about 40% of UTI-related prescriptions are second-line antibiotics, which contributes to emerging resistance rates. To achieve a change in the prescribing behaviour among family physicians (FPs), this trial aims to implement the guideline recommendations in German family medicine.

Methods/design: In a randomized controlled trial, a multimodal intervention will be developed and tested in family practices in four regions across Germany. The intervention will consist of three elements: information on guideline recommendations, information on regional resistance and feedback of prescribing behaviour for FPs on a quarterly basis. The effect of the intervention will be compared to usual practice. The primary endpoint is the absolute difference in the mean of prescribing rates of second-line antibiotics among the intervention and the control group after 12 months. To detect a 10% absolute difference in the prescribing rate after one year, with a significance level of 5% and a power of 86%, a sample size of 57 practices per group will be needed. Assuming a dropout rate of 10%, an overall number of 128 practices will be required. The accompanying process evaluation will provide information on feasibility and acceptance of the intervention.

Discussion: If proven effective and feasible, the components of the intervention can improve adherence to antibiotic prescribing guidelines and contribute to antimicrobial stewardship in ambulatory care.
KW  - antibiotic resistance
KW  - urinary tract infections
KW  - guideline adherence
KW  - multimodal
KW  - family physicians
KW  - primary care
Y1  - 2021
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/26472
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-264725
VL  - 21
ER  -