TY  - JOUR
A1  - Zech, Linda D.
A1  - Scherf-Clavel, Maike
A1  - Daniels, Christine
A1  - Schwab, Michael
A1  - Deckert, Jürgen
A1  - Unterecker, Stefan
A1  - Herr, Alexandra S.
T1  - Patients with higher vitamin D levels show stronger improvement of self-reported depressive symptoms in psychogeriatric day-care setting
T2  - Journal of Neural Transmission
N2  - Depression is a common psychiatric disorder among geriatric patients that decreases the quality of life and increases morbidity and mortality. Vitamin D as a neuro-steroid hormone might play a role in the onset and treatment of depression. In the present study, the association between depressive symptoms and vitamin D concentration in serum was evaluated. 140 patients of a psychogeriatric day-care unit were included. The geriatric depression scale (GDS) and the Hamilton depression rating scale (HDRS) were assessed at the beginning and end of treatment, GDS scores additionally 6 weeks after discharge from the day-care unit. Vitamin D levels were measured at the beginning of the treatment, routinely. Patients with levels below 30 µg/L were treated with 1000 IU vitamin D per day. There was no association between the severity of depressive symptoms and the concentration of vitamin D at the beginning of the treatment. Patients with higher vitamin D levels showed a stronger decline of depressive symptoms measured by the GDS during their stay in the day-care unit. We provide evidence that vitamin D serum levels might influence antidepressant therapy response in a geriatric population. Prospective studies are necessary to determine which patients may profit from add-on vitamin D therapy.
KW  - anti-depressive treatment
KW  - psycho-geriatrics
KW  - vitamin D deficiency
KW  - depression
Y1  - 2021
UR  - https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/26852
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-268525
SN  - 1435-1463
VL  - 128
IS  - 8
ER  -