@article{MaierWeissenbergerRudertetal.2021,
  author    = {Maier, Gerrit S. and Weissenberger, Manuel and Rudert, Maximilian and Roth, Klaus E. and Horas, Konstantin},
  title     = {The role of vitamin D and vitamin D deficiency in orthopaedics and traumatology—a narrative overview of the literature},
  series = {Annals of Translational Medicine},
  volume    = {9},
  journal   = {Annals of Translational Medicine},
  doi       = {10.21037/atm-21-779},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-370110},
  year      = {2021},
  abstract  = {Vitamin D is considered to play an important role in musculoskeletal health. It's classical function is the regulation of calcium and phosphate homeostasis, thus ensuring a balanced bone metabolism that is characterised by an equal amount of bone resorption and bone formation. In the past decades, a plethora of pre-clinical and clinical studies reporting on potential health-beneficial properties of vitamin D have emerged. Moreover, there is an abundance of reports highlighting vitamin D deficiency and insufficiency in patients with almost innumerable diseases. Further, it is estimated that more than one billion people globally are affected by insufficient vitamin D levels. As such, research on vitamin D has been particularly popular over the past years. In orthopaedics and traumatology, most studies describe favourable effects of vitamin D in general. However, the relative importance of vitamin D is oftentimes debated. In this narrative review of the literature, we consider first, the properties of vitamin D and how vitamin D, vitamin D deficiency and the vitamin D receptor (VDR) impact on musculoskeletal health. Secondly, we provide an overview of studies reporting the prevalence of vitamin D deficiency in traumatology and diverse orthopaedic diseases including bone oncology. Lastly, we emphasise recent findings and touch on future perspectives in vitamin D research.},
  language  = {en}
}