@article{AdamWittbrodtTellingetal.1988,
  author    = {Adam, D. and Wittbrodt, J. and Telling, A. and Schartl, Manfred},
  title     = {RFLP for an EGF-receptor related gene associated with the melanoma oncogene locus of Xiphophorus maculatus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61822},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@article{AdamDimitrijevicSchartl1993,
  author    = {Adam, Dieter and Dimitrijevic, Nicola and Schartl, Manfred},
  title     = {Tumor suppression in Xiphophorus by an accidentally acquired promoter},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61630},
  year      = {1993},
  abstract  = {Melanoma formation in the teleost Xiphophorus is caused by a dominant genetic locus, Tu. This locus includes the Xmrk oncogene, which encodes a receptor tyrosine kinase. Tumor induction is. suppressed in wild-type fish by a tumor suppressor locus, R. Molecular genetic analyses revealed that the Tu locus emerged by nonhomologaus recombination of the Xmrk proto-oncogene with a previously uncharacterized sequence, D. This event generated an additional copy of Xmrk with a new promoter. Suppression of the new Xmrk promoter by R in parental fish and its deregulation in hybrids explain the genetics of melanoma formation in Xiphophorus.},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@article{BarnekowPaulSchartl1987,
  author    = {Barnekow, A. and Paul, E. and Schartl, Manfred},
  title     = {Expression of the c-src protooncogene in human skin tumors},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61870},
  year      = {1987},
  abstract  = {No abstract available},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@article{BarnekowSchartl1987,
  author    = {Barnekow, A. and Schartl, Manfred},
  title     = {Comparative studies on the src proto-oncogene and its gene product pp60\(^{c-src}\) in normal and neoplastic tissues of lower vertebrates},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61869},
  year      = {1987},
  abstract  = {No abstract available},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@article{BarnekowSchartlAndersetal.1982,
  author    = {Barnekow, A. and Schartl, Manfred and Anders, F. and Bauer, H.},
  title     = {Identification of a fish protein associated with a kinase activity and related to the Rous sarcoma virus transforming protein},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61946},
  year      = {1982},
  abstract  = {No abstract available},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@article{BernardsSchacklefordGerberetal.1989,
  author    = {Bernards, R. and Schackleford, G. M. and Gerber, M. R. and Horowitz, J. M. and Friend, S. H. and Schartl, Manfred and Bogenmann, E. and Rapaport, J. M. and Mcgee, T. and Dryja, T. P.},
  title     = {Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61819},
  year      = {1989},
  abstract  = {No abstract available},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@article{CavariHongFunkensteinetal.1993,
  author    = {Cavari, Benzion and Hong, Yunhan and Funkenstein, Bruria and Moav, Boaz and Schartl, Manfred},
  title     = {All-fish gene constructs for growth hormone gene transfer in fish},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61612},
  year      = {1993},
  abstract  = {In order to develop all-fish expression vectors for microinjection into fertilized fish eggs, we have prepared the following cunstructs: rainbow trout metallothionein a/b and the gilthead seabream growth hormone cDNA (ptMTa-gbsGHcDNA, ptMTb-gsbGHcDNA), carp ß-actin gilthead seabream GH cDNA (pcAßgsbGHcDNA). The inducible metallothionein promoters a and b were cloned from rainbow trout, and the constitutive promoter ß-actin was isolated from carp. The metallothionein promoters were cloned by using the PCR technique. The tMTa contains 430 bp, while the tMTb contains 260 bp (Hong et al. 1992). These two promoters were introduced to pGEM-3Z containing the GH cDNA of Sparus aurata to form ptMTa-gsbGH and ptMTb-gsbGH, respectively. The carp cytoplasmic ß-actin gene was chosen as a source for isolating strong constitutive regulatory sequences. One of these regulatory sequences in pUC118 was Iigated to GH cDNA of S. aurata to form the pcAß-gsbGHcDNA. Expression of the constructs containing the metallothionein promoters was tested in fish cell culture and was found tobe induced effectively by zinc. The ptMTa gsb-GH cDNA construct was microinjected into fertilized carp eggs, and integration in the genome of carp was detected in the DNA isolated from fins at the age of two months.},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@article{ClaussWinklerLohmeyeretal.1990,
  author    = {Clauss, Gerd and Winkler, Christoph and Lohmeyer, J{\"u}rgen and Anders, Fritz and Schartl, Manfred},
  title     = {Oncofetal antigen in Xiphophorus detected by monoclonal antibodies directed against melanoma-associated antigens},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61784},
  year      = {1990},
  abstract  = {Monoclonal antlbodies (MAbs) directed against Xiphophorus melanoma cells were deve(oped and tested by lndirect immunofluorescence and Immunoperoxidase staining for reactivity with a panel of I 5 allogeneic tissues and 12 allogeneic cell llnes. The reactivity of such MAbs was restricted to melanoma cells from tumor biopsies and melanoma-derived cell lines. ln addition, all embryonie cells of all histiotypes from developmental stages later than mld·organogenesis and from corresponding short term in vitro cultures reacted with these MAbs. ln contrast, normal tissues and organs from adult fish dlsplayed no reactivity, thus implying that the melanoma-associated antigens detected by the MAbs described are oncofetal antigens.},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@article{DracopoliFeltquateSametal.1990,
  author    = {Dracopoli, Nicholas C. and Feltquate, David M. and Sam, Brigitta and Schartl, Manfred},
  title     = {Taql and Mspl RFLPs are detected by the human 2,3-biphosphoglycerate mutase (BPGM) cDNA},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61763},
  year      = {1990},
  abstract  = {No abstract available},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@article{ErbeldingDenkSchroderSchartletal.1994,
  author    = {Erbelding-Denk, Claudia and Schroder, Johannes H. and Schartl, Manfred and Nanda, Indrajit and Schmid, Michael and Epplen, J{\"o}rg T.},
  title     = {Male polymorphism in Limia perugiae (Pisces: Poeciliidae)},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61573},
  year      = {1994},
  abstract  = {The male-polymorphic poeciliid fish, Limia perugiae, a small teleostean endemic to the southeast of the Caribbean island Hispafiola, consists of three male size morphs with uniform females. Large males differentiate at a size va:rying between 25 and 38 mm; intermediate males, between 21 and 25 mm. Under competition, !arge males exhibit an elaborate courtship display, whereas small males show only a sneak-chase behavior. Intermediate males adapt their tactics to the respective competitors. However, all malemorphs can switch from courtship display to sneak-chase behavior. In large mating groups with four males of different size and five or six virgin females, large dominant a-males as weil as small subordinate \(\delta\)-males did not produce any offspring. Unexpectedly, all progeny were sired exclusively by the intemediate subordinate ß- and \(\gamma\)-males. Breeding experiments with the three male morphs can best be explained by a model of Y -linked genes for small and !arge size which are both suspended by the activity of an autosomal recessive repressor responsible for the development of intermediate males. The dominant allele of the recessive repressor, in either its homoorits heterozygous state, activates the Y-chromosomal genes for !arge or small size, respectively. Accordingly, intermediate males may produce male offspring of all size classes, depending on the presence of either the Y-linked gene or the autosomal repressor.},
  subject      = {Physiologische Chemie},
  language  = {en}
}