@article{MeyerSchartl1979,
  author    = {Meyer, Manfred K. and Schartl, Manfred},
  title     = {Eine neue Xiphophorus-Art aus Vera Cruz, Mexiko : (Pisces: Poeciliidae)},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87124},
  year      = {1979},
  abstract  = {Xiphophorus andersi n. sp. from the Rio Atoyac, Vera Cruz, Mexico is described: lang head, moderately slender body, large dark black spar at the basis of the anal fin; adult male with short sword-like caudal appendage; rip of ray 5a of gonopodium without a developed claw. Xiphophorus andersi n. sp. differs by the combination of distinct characters from all the other species of the genus known so far. The new species shows features of both the so-called platyfish species group and the so-called swordtail species group.},
  subject      = {Schwertk{\"a}rpfling},
  language  = {en}
}
@article{SchartlSchroeder1987,
  author    = {Schartl, Manfred and Schr{\"o}der, Johannes Horst},
  title     = {A new species of the genus Xiphophorus Heckel 1848, endemic to northern Coahuila, Mexico (Pisces: Poeciliidae)},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87117},
  year      = {1987},
  abstract  = {Xiphophorus meyeri n. sp. is described as an endemic to Muzquiz, Coahuila, Mexico. It appears to be the northernmost species of the genus. The new species is related to X. couchianus and X. gordoni, but differs morphologically from those by dorsal fin ray number, by the expression of some gonopodial features and most markedly by the appearance of macromelanophores or tr-melanophores.},
  subject      = {Schwertkr{\"a}pfling},
  language  = {en}
}
@article{WinklerWittbrodtLammersetal.1994,
  author    = {Winkler, Christoph and Wittbrodt, Joachim and Lammers, Reiner and Ullrich, Axel and Schartl, Manfred},
  title     = {Ligand-dependent tumor induction in medakafish embryos by a Xmrk receptor tyrosine kinase transgene},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87107},
  year      = {1994},
  abstract  = {Xmrk encodes a subclass 1 receptor tyrosine kinase (RTK) which has been cloned from the melanomainducing locus Tu of the poeciliid fish Xiphophorus. To demonstrate a high oncogenic potential in vivo we transferred the gene into early embryos of the closely related medakafish. Ectopic expression of the Xmrk oncogene under the control of a strong, constitutive promoter (CMVTk) led to the induction of embryonic tumors with high incidence, after short latency periods, and with a specific pattern of affected tissues. We demonstrate ligand-dependent transformation in vivo using a chimeric receptor consisting of the extracellular and transmembrane domains of the human EGF receptor (HER) and the cytoplasmatic domain of Xmrk. Expression of the chimeric receptor alone does not lead to ldnase activation or induction of tumors. Coexpression of the chimera with its corresponding ligand, human transforming growth factor alpha (bTGF(X), however, results in the activation of the chimeric RTK. In injected fish embryos the induction of the neoplastic growth is observed with similar incidence and tissue distribution as in embryos carrying the native Xmrk oncogene suggesting that the ligand as well as factors downstream of tbe RTK are required for tumor formation. In this study we show single-step induction of tumors by ectopic expression of RTKs in vivo substantiating tbe significance of autocrine stimulation in RTK induced tumors in vertebrales.},
  subject      = {Japank{\"a}rpfling},
  language  = {en}
}
@article{WinklerHongWittbrodtetal.1992,
  author    = {Winkler, Christoph and Hong, Yunhan and Wittbrodt, Joachim and Schartl, Manfred},
  title     = {Analysis of heterologous and homologous promoters and enhancers in vitro and in vivo by gene transfer into Japanese medaka (Oryzias latipes) and Xiphophorus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86796},
  year      = {1992},
  abstract  = {Efficient expression systems are required for analysis of gene regulation and function in teleost fish. To develop such systems, a nurober of inducible or constitutive promoter and enhancer sequences of fish or higher vertebrate origin were tested for activity in a variety of fish celllines andin embryos of the Japanese medaka fish (Oryzias latipes) and Xiphophorus. The activity of the different promoterenhancer combinations were quantitated. Considerable differences were found for some constructs if tested in vitro or in vivo. From the data obtained, a set of expression vectors for basic research as weH as for aquaculture purposes were established.},
  subject      = {Schwertk{\"a}rpfling},
  language  = {en}
}
@article{FoersterSchartl1987,
  author    = {Foerster, Wolfgang and Schartl, Manfred},
  title     = {Karyotype and isozyme patterns of five species of Aulonocara REGAN, 1922},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86774},
  year      = {1987},
  abstract  = {No abstract available.},
  subject      = {Aulonocara},
  language  = {en}
}
@article{HannigOttilieSchartl1991,
  author    = {Hannig, Gerhard and Ottilie, Sabine and Schartl, Manfred},
  title     = {Conservation of structure and expression of the c-yes and fyn genes in lower vertebrates},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86723},
  year      = {1991},
  abstract  = {The src-gene family in mammals and birds consists of 9 closely related protein tyrosine kinases. We have cloned the c-yes and fyn bomologues of the src-family from the teleost fish Xiphophorus helleri. Both genes show a high degree of sequence conservation and exhibit all structural motifs diagnostic for functional src-like protein tyrosine kinases. Sequence comparisons revealed three domains (exon 2, exons 3--6, exons 7-12) which evolve at different rates. Both genes exhibit an identical expression pattern, with preferential expression in neural tissues. No transcripts of c-yes were found in liver wbich is contrary to the situation in higher vertebrales. In malignant melanoma, elevated Ieveis of c-yes andfyn were detected indicating a possible function during secondary steps of tumor progression for src-related tyrosine kinases.},
  subject      = {Konservierung},
  language  = {en}
}
@article{RaulfMaeuelerRobertsonetal.1989,
  author    = {Raulf, Friedrich and M{\"a}ueler, Winfried and Robertson, Scott M. and Schartl, Manfred},
  title     = {Localization of cellular src mRNA during development and in the differentiated bipolar neurons of the adult neural retina in Xiphophorus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86703},
  year      = {1989},
  abstract  = {The expression of the c-src gene in embryonie and adult tissue of the teleost fish Xiphophorus helleri was analyzed by in-situ hybridization. The highly conserved fish c-src gene was found to be expressed at high levels in midterm embryos, where c-src mRNA was localized in developing neurons of the sensory layer of the differentiating retina and in the developing brain. In adult tissues the expression of c-src was found to persist in certain cell types of the brain and the neural retina, especially in the bipolar cells of the inner nuclear layer, which are postmitotic, fully differentiated mature neurons. Thus c-src in Xiphophorus appears to be a developmentally regulated proto-oncogene which is important for neuronal differentiation during organogenesis, but whose persistence of expression in certain terminally differentiated neurons strongly suggests a particular maintenance function for c-src in these cells as well.},
  subject      = {Schwertk{\"a}rpfling},
  language  = {en}
}
@article{BarnekowJahnSchartl1990,
  author    = {Barnekow, Angelika and Jahn, Reinhard and Schartl, Manfred},
  title     = {Synaptophysin: a substrate for the protein tyrosine kinase pp60c-src in intact synaptic vesicles},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86168},
  year      = {1990},
  abstract  = {Expression of pp60 c-src, the first well defined proto-oncogene product, is developmentally regulated and tissue-specific, with neuronal tissues displaying high amounts of the c-src encoded pp60 c-src kinase activity. In the central nervous system pp60 s-src is preferentially expressed in regions characterized by a high content of grey matter and elevated density of nerve terminals. In this study we show for the first time a direct interaction between pp60 c-src and synaptophysin as a physiological target protein in neurons by demonstrating that endogenous pp60 c-src is able to phosphorylate synaptophysin (p38). p38 is a major constituent of the synaptic vesicle membrane protein and is thought to play a key role in the exocytosis of small synaptic vesicles and possibly small clear vesicles in neuroendocrine cells.},
  subject      = {Synaptophysin},
  language  = {en}
}
@article{SchartlSchartlAnders1982,
  author    = {Schartl, A. and Schartl, Manfred and Anders, F.},
  title     = {Promotion and regression of neoplasia by testosterone-promoted cell differentiation in Xiphophorus and Girardinus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86684},
  year      = {1982},
  abstract  = {No abstract available.},
  subject      = {Schwertk{\"a}rpfling},
  language  = {en}
}
@inproceedings{SchreibmanSchartlKallmanetal.1994,
  author    = {Schreibman, Martin P. and Schartl, Manfred and Kallman, Klaus D. and Magliulo-Cepriano, Lucia},
  title     = {Molecular approaches to study the genetic regulation of the fish reproductive system},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86679},
  year      = {1994},
  abstract  = {No abstract available.},
  subject      = {Fische},
  language  = {en}
}