@article{LvZhangZhuetal.2015,
  author    = {Lv, Xiaoqun and Zhang, Lingyun and Zhu, Yanyan and Said, Harun M. and Shi, Jimin and Xu, Guoxiong},
  title     = {Regulative effect of Nampt on tumor progression and cell viability in human colorectal cancer},
  series = {Journal of Cancer},
  volume    = {6},
  journal   = {Journal of Cancer},
  number    = {9},
  doi       = {10.7150/jca.12341},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-144516},
  pages     = {849-858},
  year      = {2015},
  abstract  = {Colorectal cancer (CRC) is the third most common cancer disease. Here we examined Nampt expression in patients with CRC and the effect of Nampt on cell viability in CRC cells. Nampt protein was overexpressed in colorectal adenoma as well as colorectal carcinoma. The immunoreactive staining of Nampt was negative in the adjacent normal colorectal tissue, weak in colorectal adenoma, and strong in colorectal carcinoma, which may represent tumor progression. Further evaluation of clinical data showed that Nampt expression was not correlated with the clinicopathological characteristics of CRC. Additionally, our in vitro studies demonstrated that Nampt promotes CRC cell viability, whereas the Nampt inhibitor FK866 suppressed CRC cell viability, which was in concordance with the previous studies in other cancer cells. Treatment with Nampt-siRNA reduced the Nampt protein expression resulting in the inhibition of the cell viability of HCT116 and Caco2. Thus, the involvement of Nampt in cell growth indicates that Nampt may play an important role in colorectal tumorigenesis. As a consequence, our results suggest that Nampt may be considered as a progression marker of colorectal tumor and a potentially therapeutic target for the treatment of CRC.},
  language  = {en}
}
@article{SagivMichaeliAssietal.2015,
  author    = {Sagiv, Jitka Y. and Michaeli, Janna and Assi, Simaan and Mishalian, Inbal and Kisos, Hen and Levy, Liran and Damti, Pazzit and Lumbroso, Delphine and Polyansky, Lola and Sionov, Ronit V. and Ariel, Amiram and Hovav, Avi-Hai and Henke, Erik and Fridlender, Zvi G. and Granot, Zvi},
  title     = {Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer},
  series = {Cell Reports},
  volume    = {10},
  journal   = {Cell Reports},
  number    = {4},
  doi       = {10.1016/j.celrep.2014.12.039},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-144102},
  pages     = {562-573},
  year      = {2015},
  abstract  = {Controversy surrounds neutrophil function in cancer because neutrophils were shown to provide both pro-and antitumor functions. We identified a heterogeneous subset of low-density neutrophils (LDNs) that appear transiently in self-resolving inflammation but accumulate continuously with cancer progression. LDNs display impaired neutrophil function and immunosuppressive properties, characteristics that are in stark contrast to those of mature, high-density neutrophils (HDNs). LDNs consist of both immature myeloid-derived suppressor cells (MDSCs) and mature cells that are derived from HDNs in a TGF-beta-dependent mechanism. Our findings identify three distinct populations of circulating neutrophils and challenge the concept that mature neutrophils have limited plasticity. Furthermore, our findings provide a mechanistic explanation to mitigate the controversy surrounding neutrophil function in cancer.},
  language  = {en}
}