@article{WeismannSchneiderHoeybye2016,
  author    = {Weismann, Dirk and Schneider, Andreas and H{\"o}ybye, Charlotte},
  title     = {Clinical aspects of symptomatic hyponatremia},
  series = {Endocrine Connections},
  volume    = {5},
  journal   = {Endocrine Connections},
  number    = {5},
  doi       = {10.1530/EC-16-0046},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-162936},
  pages     = {R35-R43},
  year      = {2016},
  abstract  = {Hyponatremia (HN) is a common condition, with a large number of etiologies and a complicated treatment. Although chronic HN has been shown to be a predictor of poor outcome, sodium-increasing treatments in chronic stable and asymptomatic HN have not proven to increase life expectancy. For symptomatic HN, in contrast, the necessity for urgent treatment has broadly been accepted to avoid the development of fatal cerebral edema. On the other hand, a too rapid increase of serum sodium in chronic HN may result in cerebral damage due to osmotic demyelinisation. Recently, administration of hypertonic saline bolus has been recommended as first-line treatment in patients with moderate-to-severe symptomatic HN. This approach is easy to memorize and holds the potential to greatly facilitate the initial treatment of symptomatic HN. First-line treatment of chronic HN is fluid restriction and if ineffective treatment with tolvaptan or in some patients other agents should be considered. A number of recommendations and guidelines have been published on HN. In the present review, the management of patients with HN in relation to everyday clinical practice is summarized with focus on the acute management.},
  language  = {en}
}
@article{LiWongNongetal.2014,
  author    = {Li, Lei and Wong, Hin-chung and Nong, Wenyan and Cheung, Man Kit and Law, Patrick Tik Wan and Kam, Kai Man and Kwan, Hoi Shan},
  title     = {Comparative genomic analysis of clinical and environmental strains provides insight into the pathogenicity and evolution of Vibrio parahaemolyticus},
  series = {BMC Genomics},
  volume    = {15},
  journal   = {BMC Genomics},
  number    = {1135},
  issn      = {1471-2164},
  doi       = {10.1186/1471-2164-15-1135},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-118080},
  year      = {2014},
  abstract  = {Background: Vibrio parahaemolyticus is a Gram-negative halophilic bacterium. Infections with the bacterium could become systemic and can be life-threatening to immunocompromised individuals. Genome sequences of a few clinical isolates of V. parahaemolyticus are currently available, but the genome dynamics across the species and virulence potential of environmental strains on a genome-scale have not been described before. Results: Here we present genome sequences of four V. parahaemolyticus clinical strains from stool samples of patients and five environmental strains in Hong Kong. Phylogenomics analysis based on single nucleotide polymorphisms revealed a clear distinction between the clinical and environmental isolates. A new gene cluster belonging to the biofilm associated proteins of V. parahaemolyticus was found in clincial strains. In addition, a novel small genomic island frequently found among clinical isolates was reported. A few environmental strains were found harboring virulence genes and prophage elements, indicating their virulence potential. A unique biphenyl degradation pathway was also reported. A database for V. parahaemolyticus (http://kwanlab.bio.cuhk.edu.hk/vp webcite) was constructed here as a platform to access and analyze genome sequences and annotations of the bacterium. Conclusions: We have performed a comparative genomics analysis of clinical and environmental strains of V. parahaemolyticus. Our analyses could facilitate understanding of the phylogenetic diversity and niche adaptation of this bacterium. "},
  language  = {en}
}