@article{SchlauersbachHanioRaschigetal.2022,
  author    = {Schlauersbach, Jonas and Hanio, Simon and Raschig, Martina and Lenz, Bettina and Scherf-Cavel, Oliver and Meinel, Lorenz},
  title     = {Bile and excipient interactions directing drug pharmacokinetics in rats},
  series = {European Journal of Pharmaceutics and Biopharmaceutics},
  volume    = {178},
  journal   = {European Journal of Pharmaceutics and Biopharmaceutics},
  edition   = {accepted version},
  doi       = {10.1016/j.ejpb.2022.07.016},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-296969},
  pages     = {65-68},
  year      = {2022},
  abstract  = {Bile solubilization plays a major role in the absorption of poorly water-soluble drugs. Excipients used in oral drug formulations impact bile-colloidal properties and their molecular interactions. Polymer-induced changes of bile colloids, e.g., by Eudragit E, reduced the flux of the bile interacting drug Perphenazine whereas bile non-interacting Metoprolol was not impacted. This study corroborates these in vitro findings in rats. Eudragit E significantly reduced systemic availability of Perphenazine but not Metoprolol compared to the oral administrations without polymer. This study confirms the necessity to carefully select polymers for bile interacting drugs whereas non-bile interacting drugs are more robust in terms of excipient choice for formulation. The perspective of bile interaction may introduce interesting biopharmaceutical leverage for better performing oral formulations of tomorrow.},
  language  = {en}
}
@article{SpangardtKesslerDobrzewskietal.2022,
  author    = {Spangardt, Christoph and Keßler, Christoph and Dobrzewski, Ramona and Tepler, Antonia and Hanio, Simon and Klaubert, Bernd and Meinel, Lorenz},
  title     = {Leveraging dissolution by autoinjector designs},
  series = {Pharmaceutics},
  volume    = {14},
  journal   = {Pharmaceutics},
  number    = {11},
  issn      = {1999-4923},
  doi       = {10.3390/pharmaceutics14112544},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297271},
  year      = {2022},
  abstract  = {Chemical warfare or terrorism attacks with organophosphates may place intoxicated subjects under immediate life-threatening and psychologically demanding conditions. Antidotes, such as the oxime HI-6, which must be formulated as a powder for reconstitution reflecting the molecule's light sensitivity and instability in aqueous solutions, dramatically improve recovery—but only if used soon after exposure. Muscle tremors, anxiety, and loss of consciousness after exposure jeopardize proper administration, translating into demanding specifications for the dissolution of HI-6. Reflecting the patients' catastrophic situation and anticipated desire to react immediately to chemical weapon exposure, the dissolution should be completed within ten seconds. We are developing multi-dose and single-dose autoinjectors to reliably meet these dissolution requirements. The temporal and spatial course of dissolution within the various autoinjector designs was profiled colorimetrically. Based on these colorimetric insights with model dyes, we developed experimental setups integrating online conductometry to push experiments toward the relevant molecule, HI-6. The resulting blueprints for autoinjector designs integrated small-scale rotor systems, boosting dissolution across a wide range of viscosities, and meeting the required dissolution specifications driven by the use of these drug products in extreme situations.},
  language  = {en}
}