@article{AbdelmohsenYangHornetal.2014,
  author    = {Abdelmohsen, Usama Ramadan and Yang, Chen and Horn, Hannes and Hajjar, Dina and Ravasi, Timothy and Hentschel, Ute},
  title     = {Actinomycetes from Red Sea Sponges: Sources for Chemical and Phylogenetic Diversity},
  doi       = {10.3390/md12052771},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-112882},
  year      = {2014},
  abstract  = {The diversity of actinomycetes associated with marine sponges collected off Fsar Reef (Saudi Arabia) was investigated in the present study. Forty-seven actinomycetes were cultivated and phylogenetically identified based on 16S rRNA gene sequencing and were assigned to 10 different actinomycete genera. Eight putatively novel species belonging to genera Kocuria, Mycobacterium, Nocardia, and Rhodococcus were identified based on sequence similarity values below 98.2\% to other 16S rRNA gene sequences available in the NCBI database. PCR-based screening for biosynthetic genes including type I and type II polyketide synthases (PKS-I, PKS-II) as well as nonribosomal peptide synthetases (NRPS) showed that 20 actinomycete isolates encoded each at least one type of biosynthetic gene. The organic extracts of nine isolates displayed bioactivity against at least one of the test pathogens, which were Gram-positive and Gram-negative bacteria, fungi, human parasites, as well as in a West Nile Virus protease enzymatic assay. These results emphasize that marine sponges are a prolific resource for novel bioactive actinomycetes with potential for drug discovery.},
  subject      = {Meeresschw{\"a}mme},
  language  = {en}
}
@article{HentschelKamkeRinkeetal.2014,
  author    = {Hentschel, Ute and Kamke, Janine and Rinke, Christian and Schwientek, Patrick and Mavromatis, Kostas Mavromatis and Ivanova, Natalia and Sczyrba, Alexander and Woyke, Tanja},
  title     = {The Candidate Phylum Poribacteria by Single-Cell Genomics: New Insights into Phylogeny, Cell-Compartmentation, Eukaryote-Like Repeat Proteins, and Other Genomic Features},
  doi       = {10.1371/journal.pone.0087353},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-112649},
  year      = {2014},
  abstract  = {The candidate phylum Poribacteria is one of the most dominant and widespread members of the microbial communities residing within marine sponges. Cell compartmentalization had been postulated along with their discovery about a decade ago and their phylogenetic association to the Planctomycetes, Verrucomicrobia, Chlamydiae superphylum was proposed soon thereafter. In the present study we revised these features based on genomic data obtained from six poribacterial single cells. We propose that Poribacteria form a distinct monophyletic phylum contiguous to the PVC superphylum together with other candidate phyla. Our genomic analyses supported the possibility of cell compartmentalization in form of bacterial microcompartments. Further analyses of eukaryote-like protein domains stressed the importance of such proteins with features including tetratricopeptide repeats, leucin rich repeats as well as low density lipoproteins receptor repeats, the latter of which are reported here for the first time from a sponge symbiont. Finally, examining the most abundant protein domain family on poribacterial genomes revealed diverse phyH family proteins, some of which may be related to dissolved organic posphorus uptake.},
  language  = {en}
}