@article{GreefrathOldenburgSilleretal.2023,
  author    = {Greefrath, Gilbert and Oldenburg, Reinhard and Siller, Hans-Stefan and Ulm, Volker and Weigand, Hans-Georg},
  title     = {Mathematics students' characteristics of basic mental models of the derivative},
  series = {Journal f{\"u}r Mathematik-Didaktik},
  volume    = {44},
  journal   = {Journal f{\"u}r Mathematik-Didaktik},
  number    = {1},
  issn      = {0173-5322},
  doi       = {10.1007/s13138-022-00207-9},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-324317},
  pages     = {143-169},
  year      = {2023},
  abstract  = {The concept of derivative is characterised with reference to four basic mental models. These are described as theoretical constructs based on theoretical considerations. The four basic mental models—local rate of change, tangent slope, local linearity and amplification factor—are not only quantified empirically but are also validated. To this end, a test instrument for measuring students' characteristics of basic mental models is presented and analysed regarding quality criteria. Mathematics students (n = 266) were tested with this instrument. The test results show that the four basic mental models of the derivative can be reconstructed among the students with different characteristics. The tangent slope has the highest agreement values across all tasks. The agreement on explanations based on the basic mental model of rate of change is not as strongly established among students as one would expect due to framework settings in the school system by means of curricula and educational standards. The basic mental model of local linearity plays a rather subordinate role. The amplification factor achieves the lowest agreement values. In addition, cluster analysis was conducted to identify different subgroups of the student population. Moreover, the test results can be attributed to characteristics of the task types as well as to the students' previous experiences from mathematics classes by means of qualitative interpretation. These and other results of students' basic mental models of the derivative are presented and discussed in detail.},
  language  = {en}
}
@article{ButtHowardRaman2022,
  author    = {Butt, Elke and Howard, Cory M. and Raman, Dayanidhi},
  title     = {LASP1 in cellular signaling and gene expression: more than just a cytoskeletal regulator},
  series = {Cells},
  volume    = {11},
  journal   = {Cells},
  number    = {23},
  issn      = {2073-4409},
  doi       = {10.3390/cells11233817},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297447},
  year      = {2022},
  abstract  = {LIM and SH3 protein 1 was originally identified as a structural cytoskeletal protein with scaffolding function. However, recent data suggest additional roles in cell signaling and gene expression, especially in tumor cells. These novel functions are primarily regulated by the site-specific phosphorylation of LASP1. This review will focus on specific phosphorylation-dependent interaction between LASP1 and cellular proteins that orchestrate primary tumor progression and metastasis. More specifically, we will describe the role of LASP1 in chemokine receptor, and PI3K/AKT signaling. We outline the nuclear role for LASP1 in terms of epigenetics and transcriptional regulation and modulation of oncogenic mRNA translation. Finally, newly identified roles for the cytoskeletal function of LASP1 next to its known canonical F-actin binding properties are included.},
  language  = {en}
}
@article{LatifiValbuena2019,
  author    = {Latifi, Hooman and Valbuena, Ruben},
  title     = {Current trends in forest ecological applications of three-dimensional remote sensing: Transition from experimental to operational solutions?},
  series = {Forests},
  volume    = {10},
  journal   = {Forests},
  number    = {10},
  issn      = {1999-4907},
  doi       = {10.3390/f10100891},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-193282},
  year      = {2019},
  abstract  = {The alarming increase in the magnitude and spatiotemporal patterns of changes in composition, structure and function of forest ecosystems during recent years calls for enhanced cross-border mitigation and adaption measures, which strongly entail intensified research to understand the underlying processes in the ecosystems as well as their dynamics. Remote sensing data and methods are nowadays the main complementary sources of synoptic, up-to-date and objective information to support field observations in forest ecology. In particular, analysis of three-dimensional (3D) remote sensing data is regarded as an appropriate complement, since they are hypothesized to resemble the 3D character of most forest attributes. Following their use in various small-scale forest structural analyses over the past two decades, these sources of data are now on their way to be integrated in novel applications in fields like citizen science, environmental impact assessment, forest fire analysis, and biodiversity assessment in remote areas. These and a number of other novel applications provide valuable material for the Forests special issue "3D Remote Sensing Applications in Forest Ecology: Composition, Structure and Function", which shows the promising future of these technologies and improves our understanding of the potentials and challenges of 3D remote sensing in practical forest ecology worldwide.},
  language  = {en}
}
@article{BrillSchwab2019,
  author    = {Brill, Michael and Schwab, Frank},
  title     = {A mixed-methods approach using self-report, observational time series data, and content analysis for process analysis of a media reception phenomenon},
  series = {Frontiers in Psychology},
  volume    = {10},
  journal   = {Frontiers in Psychology},
  doi       = {10.3389/fpsyg.2019.01666},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-201380},
  pages     = {1666},
  year      = {2019},
  abstract  = {Due to the complexityof research objects, theoretical concepts, and stimuli in media research, researchers in psychology and communications presumably need sophisticated measures beyond self-report scales to answer research questions on media use processes. The present study evaluates stimulus-dependent structure in spontaneous eye-blink behavior as an objective, corroborative measure for the media use phenomenon of spatial presence. To this end, a mixed methods approach is used in an experimental setting to collect, combine, analyze, and interpret data from standardized participant self-report, observation of participant behavior, and content analysis of the media stimulus. T-pattern detection is used to analyze stimulus-dependent blinking behavior, and this structural data is then contrasted with self-report data. The combined results show that behavioral indicators yield the predicted results, while self-report data shows unpredicted results that are not predicted by the underlying theory. The use of a mixed methods approach offered insights that support further theory development and theory testing beyond a traditional, mono-method experimental approach.},
  language  = {en}
}
@article{KaltdorfSrivastavaGuptaetal.2016,
  author    = {Kaltdorf, Martin and Srivastava, Mugdha and Gupta, Shishir K. and Liang, Chunguang and Binder, Jasmin and Dietl, Anna-Maria and Meir, Zohar and Haas, Hubertus and Osherov, Nir and Krappmann, Sven and Dandekar, Thomas},
  title     = {Systematic Identification of Anti-Fungal Drug Targets by a Metabolic Network Approach},
  series = {Frontiers in Molecular Bioscience},
  volume    = {3},
  journal   = {Frontiers in Molecular Bioscience},
  doi       = {10.3389/fmolb.2016.00022},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-147396},
  pages     = {22},
  year      = {2016},
  abstract  = {New antimycotic drugs are challenging to find, as potential target proteins may have close human orthologs. We here focus on identifying metabolic targets that are critical for fungal growth and have minimal similarity to targets among human proteins. We compare and combine here: (I) direct metabolic network modeling using elementary mode analysis and flux estimates approximations using expression data, (II) targeting metabolic genes by transcriptome analysis of condition-specific highly expressed enzymes, and (III) analysis of enzyme structure, enzyme interconnectedness ("hubs"), and identification of pathogen-specific enzymes using orthology relations. We have identified 64 targets including metabolic enzymes involved in vitamin synthesis, lipid, and amino acid biosynthesis including 18 targets validated from the literature, two validated and five currently examined in own genetic experiments, and 38 further promising novel target proteins which are non-orthologous to human proteins, involved in metabolism and are highly ranked drug targets from these pipelines.},
  language  = {en}
}
@phdthesis{Qiu2008,
  author    = {Qiu, Liyan},
  title     = {Structural and functional analysis of crossveinless 2 / BMP-2 /Chordin interaction},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-29249},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2008},
  abstract  = {No abstract available},
  language  = {en}
}