@article{RockelWagnerSpengeretal.2023,
  author    = {Rockel, Anna F. and Wagner, Nicole and Spenger, Peter and Erg{\"u}n, S{\"u}leyman and W{\"o}rsd{\"o}rfer, Philipp},
  title     = {Neuro-mesodermal assembloids recapitulate aspects of peripheral nervous system development \(in\) \(vitro\)},
  series = {Stem Cell Reports},
  volume    = {18},
  journal   = {Stem Cell Reports},
  number    = {5},
  issn      = {2213-6711},
  doi       = {10.1016/j.stemcr.2023.03.012},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-349925},
  pages     = {1155-1165},
  year      = {2023},
  abstract  = {Summary Here we describe a novel neuro-mesodermal assembloid model that recapitulates aspects of peripheral nervous system (PNS) development such as neural crest cell (NCC) induction, migration, and sensory as well as sympathetic ganglion formation. The ganglia send projections to the mesodermal as well as neural compartment. Axons in the mesodermal part are associated with Schwann cells. In addition, peripheral ganglia and nerve fibers interact with a co-developing vascular plexus, forming a neurovascular niche. Finally, developing sensory ganglia show response to capsaicin indicating their functionality. The presented assembloid model could help to uncover mechanisms of human NCC induction, delamination, migration, and PNS development. Moreover, the model could be used for toxicity screenings or drug testing. The co-development of mesodermal and neuroectodermal tissues and a vascular plexus along with a PNS allows us to investigate the crosstalk between neuroectoderm and mesoderm and between peripheral neurons/neuroblasts and endothelial cells. Highlights •Novel neuro-mesodermal assembloid model of peripheral nervous system development •Model covers neural crest cell induction, migration, and ganglion formation •Ganglia send projections to the mesodermal as well as neural compartment •Peripheral ganglia and nerve fibers interact with a co-developing vascular plexus},
  language  = {en}
}
@article{ElsnerKunzWagneretal.2023,
  author    = {Elsner, Clara and Kunz, Andreas Steven and Wagner, Nicole and Huflage, Henner and H{\"u}bner, Stefan and Luetkens, Karsten Sebastian and Bley, Thorsten Alexander and Schmitt, Rainer and Erg{\"u}n, S{\"u}leyman and Grunz, Jan-Peter},
  title     = {MRI-based evaluation of the flexor digitorum superficialis anatomy: investigating the prevalence and morphometry of the "chiasma antebrachii"},
  series = {Diagnostics},
  volume    = {13},
  journal   = {Diagnostics},
  number    = {14},
  issn      = {2075-4418},
  doi       = {10.3390/diagnostics13142406},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-362631},
  year      = {2023},
  abstract  = {Recent dissection studies resulted in the introduction of the term "chiasma antebrachii", which represents an intersection of the flexor digitorum superficialis (FDS) tendons for digits 2 and 3 in the distal third of the forearm. This retrospective investigation aimed to provide an MRI-based morphologic analysis of the chiasma antebrachii. In 89 patients (41 women, 39.3 ± 21.3 years), MRI examinations of the forearm (2010-2021) were reviewed by two radiologists, who evaluated all studies for the presence and length of the chiasma as well as its distance from the distal radioulnar and elbow joint. The chiasma antebrachii was identified in the distal third of the forearm in 88 patients (98.9\%), while one intersection was located more proximally in the middle part. The chiasma had a median length of 28 mm (interquartile range: 24-35 mm). Its distances to the distal radioulnar and elbow joint were 16 mm (8-25 mm) and 215 mm (187-227 mm), respectively. T1-weighted post-contrast sequences were found to be superior to T2- or proton-density-weighted sequences in 71 cases (79.8\%). To conclude, the chiasma antebrachii is part of the standard FDS anatomy. Knowledge of its morphology is important, e.g., in targeted injections of therapeutics or reconstructive surgery.},
  language  = {en}
}