@article{RiadZlotosHolzgrabe2015,
  author    = {Riad, Noura M. and Zlotos, Darius P. and Holzgrabe, Ulrike},
  title     = {Crystal structure of 5,11-dihydropyrido[2,3-b][1,4]benzodiazepin-6-one.},
  series = {Acta Crystallographica Section E Crystallographic Communications},
  volume    = {E71},
  journal   = {Acta Crystallographica Section E Crystallographic Communications},
  doi       = {10.1107/S2056989015006817},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-149627},
  pages     = {o304-o305},
  year      = {2015},
  abstract  = {The title compound, C\(_{12}\)H\(_{9}\)N\(_{3}\)O, is an inter­mediate in the synthesis of the muscarinic M2 receptor antagonist AFDX-384. The seven-membered ring adopts a boat conformation and the dihedral angle between the planes of the aromatic rings is 41.51 (9)°. In the crystal, mol­ecules are linked into [001] chains of alternating inversion dimers formed by pairs of N-H・・・O hydrogen bonds and pairs of N-H・・・N hydrogen bonds. In both cases, R\(_{2}\)\(^{2}\)(8) loops are generated.},
  language  = {en}
}
@article{GlaserSchurigtSuzukietal.2015,
  author    = {Glaser, Jan and Schurigt, Uta and Suzuki, Brian M. and Caffrey, Connor R. and Holzgrabe, Ulrike},
  title     = {Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl},
  series = {Molecules},
  volume    = {20},
  journal   = {Molecules},
  doi       = {10.3390/molecules200610873},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-125712},
  pages     = {10873-10883},
  year      = {2015},
  abstract  = {Bornyl caffeate (1) was previously isolated by us from Valeriana (V.) wallichii rhizomes and identified as an anti-leishmanial substance. Here, we screened a small compound library of synthesized derivatives 1-30 for activity against schistosomula of Schistosoma (S.) mansoni. Compound 1 did not show any anti-schistosomal activity. However, strong phenotypic changes, including the formation of vacuoles, degeneration and death were observed after in vitro treatment with compounds 23 (thymyl cinnamate) and 27 (eugenyl cinnamate). Electron microscopy analysis of the induced vacuoles in the dying parasites suggests that 23 and 27 interfere with autophagy.},
  language  = {en}
}
@article{GlaserSchultheisMolletal.2015,
  author    = {Glaser, Jan and Schultheis, Martina and Moll, Heidrun and Hazra, Banasri and Holzgrabe, Ulrike},
  title     = {Antileishmanial and Cytotoxic Compounds from Valeriana wallichii and Identification of a Novel Nepetolactone Derivative},
  series = {Molecules},
  volume    = {20},
  journal   = {Molecules},
  number    = {4},
  doi       = {10.3390/molecules20045740},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-125320},
  pages     = {5740-5753},
  year      = {2015},
  abstract  = {The chloroform extract of Valeriana wallichii (V. wallichii) rhizomes was investigated to elucidate the structures responsible for reported antileishmanial activity. Besides bornyl caffeate (1, already been reported by us previously), bioassay-guided fractionation resulted in two additional cinnamic acid derivatives 2-3 with moderate leishmanicidal activity. The structure of a novel nepetolactone derivative 4 having a cinnamic acid moiety was elucidated by means of spectral analysis. To the best of our knowledge villoside aglycone (5) was isolated from this plant for the first time. The bioassay-guided fractionation yielded two new (compounds 6-7) and two known valtrates (compounds 8-9) with leishmanicidal potential against Leishmania major (L. major) promastigotes. In addition, β-bisabolol (10), α-kessyl alcohol (11), valeranone (12), bornyl isovalerate (13) and linarin-2-O-methylbutyrate (14) were identified. This is the first report on the isolation of 4'-demethylpodophyllotoxin (15), podophyllotoxin (16) and pinoresinol (17) in V. wallichii. In total thirteen known and four new compounds were identified from the extract and their cytotoxic and antileishmanial properties were evaluated.},
  language  = {en}
}