@article{VermaFuehringDakroubHanetal.2022,
  author    = {Verma-Fuehring, R. and Dakroub, M. and Han, H. and Hillenkamp, J. and Loewen, N. A.},
  title     = {Trabeculopuncture as a predictive test of distal outflow resistance in canal-based surgery},
  series = {Scientific Reports},
  volume    = {12},
  journal   = {Scientific Reports},
  doi       = {10.1038/s41598-022-13990-9},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-299740},
  year      = {2022},
  abstract  = {We investigated whether trabeculopuncture (TP) could detect distal outflow resistance to predict the outcome of canal-based glaucoma surgery such as ab interno trabeculectomy (AIT). These procedures have a high utilization in open angle glaucoma, but fail in eyes with an unidentified distal outflow resistance. We assigned 81 porcine eyes to two groups: trial (n = 42) and control (n = 39). At 24 h, four YAG-laser trabeculopunctures were placed nasally, followed by a 180° AIT at the same site at 48 h. The proportion of TP responders between both AIT groups was compared. Histology and outflow canalograms were determined. Both post-TP and post-AIT IOPs were lower than baseline IOP (p = 0.015 and p < 0.01, respectively). The success rates of TP and AIT were 69\% and 85.7\%, respectively. Sensitivity and specificity values of TP as predictive test for AIT success were 77.7\% and 83.3\%, respectively. The positive and negative predictive values were 96.6\% and 38.5\%, respectively. We conclude that a 10\% reduction in IOP after TP can be used as a predictor for the success (> 20\% IOP decrease) of 180° AIT in porcine eyes.},
  language  = {en}
}
@article{StrzalkowskaStrzalkowskiAlYousefetal.2021,
  author    = {Strzalkowska, A. and Strzalkowski, P. and Al Yousef, Y. and Grehn, F. and Hillenkamp, J. and Loewen, Nils A.},
  title     = {Exact matching of trabectome-mediated ab interno trabeculectomy to conventional trabeculectomy with mitomycin C followed for 2 years},
  series = {Graefe's Archive for Clinical and Experimental Ophthalmology},
  volume    = {259},
  journal   = {Graefe's Archive for Clinical and Experimental Ophthalmology},
  issn      = {0721-832X},
  doi       = {10.1007/s00417-020-05031-w},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-235224},
  pages     = {963-970},
  year      = {2021},
  abstract  = {Purpose We used exact matching for a highly balanced comparison of ab interno trabeculectomy (AIT) with the trabectome to trabeculectomy with mitomycin C (TRAB). Methods A total of 5485 patients who underwent AIT were exact-matched to 196 TRAB patients by baseline intraocular pressure (IOP), number of glaucoma medications, and glaucoma type. Nearest-neighbor-matching was applied to age. Success was defined as a final IOP of less than 21 mmHg, IOP reduction of at least 20\% reduction from baseline, and no secondary surgical interventions. Outcomes were measured at 1, 3, 6, 12, 18, and 24 months. Results A total of 165 AIT could be matched to 165 TRAB. The mean baseline IOP was 22.3 ± 5.6 mmHg, and the baseline number of glaucoma medications was 2.7 ± 1.1 in both groups. At 24 months, IOP was reduced to 15.8 ± 5.2 mmHg in AIT and 12.4 ± 4.7 mmHg in TRAB. IOP was lower than baseline at all visits (p < 0.01) and lower in TRAB than AIT (p < 0.01). Glaucoma medications were reduced to 2.1 ± 1.3 in AIT and 0.2 ± 0.8 in TRAB. Compared to baseline, patients used fewer drops postoperatively (p < 0.01) and more infrequently in TRAB than in AIT (p > 0.01). Secondary surgical interventions had the highest impact on success and became necessary in 15 AIT and 59 TRAB patients. Thirty-two challenging events occurred in TRAB and none in AIT. Conclusion Both AIT and TRAB reduced IOP and medications. This reduction was more significant in TRAB but at the expense of four times as many secondary interventions.},
  language  = {en}
}