@article{MaternKochPetersmannetal.2020,
  author    = {Matern, Johannes and Koch, Raphael and Petersmann, Astrid and Kocher, Thomas and Eickholz, Peter and Lorenz, Katrin and Kim, Ti-Sun and Meyle, J{\"o}rg and Kaner, Doğan and Schlagenhauf, Ulrich and Gravemeier, Martina and Harks, Inga and Ehmke, Benjamin},
  title     = {Effect of periodontal therapy on adipokine biomarkers in overweight},
  series = {Journal of Clinical Periodontology},
  volume    = {47},
  journal   = {Journal of Clinical Periodontology},
  number    = {7},
  doi       = {10.1111/jcpe.13288},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-215546},
  pages     = {842 -- 850},
  year      = {2020},
  abstract  = {Aim The aim of this study was to evaluate the effect of non-surgical periodontal therapy on circulating levels of the systemic inflammation-associated biomarkers orosomucoid (ORM), high-sensitivity C-reactive protein (hsCRP), chemerin, and retinol-binding protein 4 (RBP4) in overweight or normal-weight patients with periodontitis at 27.5 months after therapy. Materials and methods This exploratory subanalysis includes patients from the ABPARO-trial (ClinicalTrials.gov NCT00707369). The per-protocol collective provided untreated periodontitis patients with high (≥28 kg/m\(^{2}\)) or moderate (21-24 kg/m\(^{2}\)) BMI. Out of the per-protocol collective, 80 patients were randomly selected and stratified for BMI group, sex, and treatment group (antibiotics/placebo), resulting in 40 overweight and normal-weight patients. Patients received non-surgical periodontal therapy and maintenance at 3-month intervals. Plasma samples from baseline and 27.5 months following initial treatment were used to measure the concentrations of ORM, hsCRP, chemerin, and RBP4. Results At the 27.5-month examination, ORM and hsCRP decreased noticeably in the overweight group (ORM: p = .001, hsCRP: p = .004) and normal-weight patients (ORM: p = .007, hsCRP: p < .001). Chemerin decreased in the overweight group (p = .048), and RBP4 concentrations remained stable. Conclusion Non-surgical periodontal therapy reduced systemically elevated inflammation-associated biomarkers in periodontitis patients. These improvements were more pronounced in overweight patients than in normal-weight patients.},
  language  = {en}
}