@article{SegevRagerZismanIsakovetal.1994, author = {Segev, Y. and Rager-Zisman, B. and Isakov, N. and Schneider-Schaulies, Sibylle and ter Meulen, V. and Udem, S. A. and Segal, S. and Wolfson, M.}, title = {Reversal of measles virus mediated increase of phosphorylating activity in persistently infected mouse neuroblastoma cells by anti measles antibodies}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62362}, year = {1994}, abstract = {No abstract available}, subject = {Virologie}, language = {en} } @article{SchneiderSchauliesSchneiderSchauliesSchusteretal.1994, author = {Schneider-Schaulies, Sibylle and Schneider-Schaulies, J{\"u}rgen and Schuster, A. and Bayer, M. and Pavlovic, J. and ter Meulen, V.}, title = {Cell type specific MxA-mediated inhibition of measles virus transcription in human brain cells}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62255}, year = {1994}, abstract = {No abstract available}, subject = {Virologie}, language = {en} } @article{HeinsenHennEisenmengeretal.1994, author = {Heinsen, Helmut and Henn, R. and Eisenmenger, W. and G{\"o}tz, M. and Bohl, J. and Bethke, B. and Lockermann, U. and P{\"u}schel, K.}, title = {Quantitative investigations on the human entorhinal area: left - right asymmetry and age-related changes}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59946}, year = {1994}, abstract = {The total nerve cell numbers in the right and in the left human entorhinal areas have been calculated by volume estimations with the Cavalieri principle and by cell density determinations with the optical disector. Thick gallocyanin-stained serial frozen sections through the parahippocampal gyrus of 22 human subjects (10 female, 12 male) ranging from 18 to 86 years were analysed. The laminar composition of gallocyanin (Nissl)-stained sections could easily be compared with Braak's (1972, 1980) pigmentoarchitectonic study, and Braak's nomenclature of the entorhinal laminas was adopted. Cellsparse laminae dissecantes can more clearly be distinguished in Nissl than in aldehydefuchsin preparations. These cell-poor dissecantes, lamina dissecans extema (dis-ext), lamina dissecans 1 (dis-1) and lamina dissecans 2 (dis-2), were excluded from nerve cell nurober determinations. An exact delineation of the entorhinal area is indispensable for any kind of quantitative investigation. We have defined the entorhinal area by the presence of pre-alpha ceil clusters and the deeper layers of lamina principalis externa (pre-beta and gamma) separated from lamina principalis interna (pri) by lamina dissecans 1 (dis-1). The human entorhinal area is quantitatively characterized by a left-sided (asymmetric) higher pre-alpha cell number and an age-related nerve cell loss in pre as well as pri layers. At variance with other CNS cortical and subcortical structures, the neuronal number of the entorhinal area appears to decrease continuously from the earliest stages analysed, although a secular trend has to be considered. The asymmetry in pre-alpha cell number is discussed in the context of higher human mental capabilities, especially language.}, subject = {Medizin}, language = {en} } @article{SchwarzHameisterGessleretal.1994, author = {Schwarz, Klaus and Hameister, Horst and Gessler, Manfred and Grzeschik, Karl-Heinz and Hansen-Hagge, Thomas E. and Bartram, Claus R.}, title = {Confirmation of the localization of the human recombination activating gene 1 (RAG1) to chromosome 11p13}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59136}, year = {1994}, abstract = {The human recombination activating gene 1 (RAGl) has previously been mapped to chromosomes 14q and 11 p. Here we confirm the chromosome 11 assignment by two independent approaches: autoradiographic and fluorescence in situ hybridization to metaphase spreads and analysis of human-hamster somatic cell hybrid DNA by the polymerase chain reaction (PCR) and Southern blotting. Our results unequivocally localize RAG1 to llp13.}, subject = {Biochemie}, language = {en} } @article{FischerLutz1994, author = {Fischer, W. H. and Lutz, Werner K.}, title = {Short communication : Mouse skin papilloma formation by chronic dermal application of 7,12-dimethylbenz[a]anthracene is not reduced by diet restriction}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60644}, year = {1994}, abstract = {No abstract available}, subject = {Toxikologie}, language = {en} } @article{GrunickePyerinEisenbrandetal.1994, author = {Grunicke, H. and Pyerin, W. and Eisenbrand, G. and Havemann, K. and Rabes, H. M. and Molling, K. and Schwab, M. and Lutz, Werner K. and Wahrendorf, J. and Schirrmacher, V.}, title = {7th International Symposium of the Division of Experimental Cancer Research (AEK) of the German Cancer Society : [Meeting report]}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60651}, year = {1994}, abstract = {No abstract available}, subject = {Toxikologie}, language = {en} } @article{SendtnerDittrichHughesetal.1994, author = {Sendtner, Michael and Dittrich, F. and Hughes, R. A. and Thoenen, H.}, title = {Actions of CNTF and neurotrophins on degenerating motoneurons : preclinical studies and clinical implications}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62939}, year = {1994}, abstract = {Spinal motoneurons innervating skeletal muscle were amongst the first neurons shown to require the presence of their target cells to develop appropriately. Isolated embryonie chick and rat motoneurons have been used to identify neurotrophic factors and cytokines capable of supporting the survival of developing motoneurons. Such factors include ciliary neurotrophic factor (CNTF), which is present physiologically in high amounts in myelinating Schwann cells of peripheral nerves, and brain-derived neurotrophic factor (BDNF) which is synthesized in skeletal muscle and, after peripheral nerve lesion. in Schwann cells. These factors have been further analyzed for their physiological significance in maintaining motoneuron function in vivo, and for their potential therapeutic usefulness in degenerative motoneuron disease. Both CNTF and BDNF are capable of rescuing injured facial motoneurons in newbom rats. Furthermore, CNTF prolongs survival and improves motor function of pmn mice, an animal model for degenerative motoneuron disease, by preventing degeneration of motoneuron axons and somata. Thus treatment of human motoneuron disease with neurotrophic factors should be possible, provided that rational means for application of these factors can be established considering also the appearance of potential side effects.}, subject = {Neurobiologie}, language = {en} } @article{ChristlTuerkPetersetal.1994, author = {Christl, Manfred and T{\"u}rk, M. and Peters, K. and Peters, E.-M. and Schnering, H. G. von}, title = {Octahydro-1,2,3:4,5,6-dimethenopentalen-2-carbonitril, das erste Derivat eines noch unbekannten (CH)\(_{10}\)-Kohlenwasserstoffs}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58728}, year = {1994}, abstract = {No abstract available}, subject = {Organische Chemie}, language = {de} } @article{ChristlTuerkPetersetal.1994, author = {Christl, Manfred and T{\"u}rk, M. and Peters, K. and Peters, E.-M. and Schnering, H. G. von}, title = {Octahydro-1,2,3:4,5,6-dimethenopentalene-2-carbonitrile, the First Derivative of a Yet-Unknown (CH)\(_{10}\)-Hydrocarbon}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58731}, year = {1994}, abstract = {No abstract available}, subject = {Organische Chemie}, language = {en} } @article{BentleyChristlKemmeretal.1994, author = {Bentley, T. W. and Christl, Manfred and Kemmer, R. and Llewellyn, G. and Oakley, J. E.}, title = {Kinetic and Spectroscopic Characterisation of Highly Reactive Methanesulfonates. Leaving Group Effects for Solvolyses and Comments on Geminal Electronic Effects Influencing S\(_N\)1 Reactivity}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58748}, year = {1994}, abstract = {Highly reactive methanesulfonates (mesylates, ROMs) have been prepared from 1-phenylethanol. cyclohex-2-en-1-ol, diphenylmethanol and p-methoxybenzyl alcohol by treatment with methanesulfonyl chloride and triethylamine in dichloro- or trichloro-methane at - 20 to 0 °C. The mesylates. characterised in solution by \(^1\)H and \(^{13}\)C NMR at -20 °C, were obtained in satisfactory purity (ca. 95\%) in cold solutions but they decomposed by reaction with chloride, triethylamine or the parent alcohol. Rate constants for solvolyses in aqueous acetone and aqueous ethanol have been determined by a fast response conductimetric method. Product selectivities for solvolyses of pmethoxybenzyl mesylate in aqueous ethanol and methanol at 0 °C have been determined by HPLC. From additional new or Iiterature kinetic data for solvolyses of corresponding bromides. chlorides and p-nitrobenzoates (OPNB). Br/CI. OMs/Br and OMs/OPNB rate ratios were calculated; the results are consistent with electronic effects stabilising the carbocationic transition states and increasing OMs/Br rate ratios for these SN 1 solvolyses; none of the evidence supports a geminal electronic effect on Br/CI rate ratios (e.g. caused by stabilisation of the initial state in pmethoxybenzyl chloride). Steric effects on ester /halide rate ratios for solvolyses of tertiary substrates are confirmed. Relative rates over a 10\(^{16}\) range for ester and halide leaving groups are evaluated for solvolyses of 1-phenylethyl substrates in 80\% ethanol-water. updating previous work by Noyce et al. (1972).}, subject = {Organische Chemie}, language = {en} }