@article{UlrichsKuhlencordtMuellerRuchholtz1979, author = {Ulrichs, Karin and Kuhlencordt, KM and M{\"u}ller-Ruchholtz, W.}, title = {Plating inhibition assay (PIA): a new test for cell mediated cytotoxicity}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45443}, year = {1979}, abstract = {No abstract available}, language = {en} } @article{DeltzMuellerHermelinkUlrichsetal.1981, author = {Deltz, E. and M{\"u}ller-Hermelink, HK and Ulrichs, Karin and Thiede, A. and M{\"u}ller-Ruchholtz, W.}, title = {Development of graft-versus-host reaction in various target organs after small intestine transplantation}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45459}, year = {1981}, abstract = {The GVHRIL foHowing transplantation of small intestine are different from those found after bone marrow transplantation or spleen cell injections in that they show a remarka ble, significant prevalence of lesions within the intestinal mucosa. These findings are consistent with the observation that jntestinal lymphocytes newly formed in mesenteric lymph nodes predominantly home in on the intestine again.\& The degree of histologic alteration within different tissues indicates that the graft and the host may survive the lesions of the lymphatic tissues, whereas the severe intestinal lesions following GVHR may easily cause death of the recipient. With regard to clinical sman bowel transplantation two statements can be made: (l) GVHRIL play a significant role in small bowel trans~ plantation. (2) To minimize their biologic importance, a selective elimination of the graft's Jymph nodes by irradiation or surgical resection should be considered in view of the remarkable difference between GVHRIL in lymph nodes and in the graft's intestinal wall itself.}, subject = {Chirurgie}, language = {en} } @article{UlrichsDeltzThiedeetal.1982, author = {Ulrichs, Karin and Deltz, E. and Thiede, A. and M{\"u}ller-Ruchholtz, W.}, title = {Lymphoid tissue transplantation in rats leads to a GVHR, inducing a specific T-cell mediated autoreactivity against MHC-antigens}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45420}, year = {1982}, abstract = {No abstract available}, language = {en} } @article{UlrichsSchangKelleretal.1984, author = {Ulrichs, Karin and Schang, T. and Keller, R. and M{\"u}ller-Ruchholtz, W.}, title = {Reactivity of pancreas islet cells with antisera of known specificity}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45466}, year = {1984}, abstract = {No abstract available}, language = {en} } @article{UlrichsYuDunckeretal.1984, author = {Ulrichs, Karin and Yu, MY and Duncker, D. and M{\"u}ller-Ruchholtz, W.}, title = {Immunosuppression by cytostatic drugs?}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45574}, year = {1984}, abstract = {In the present study, an attempt was made to characterize the immunomodulating abilities of the cytostatic drugs cydophosphamide, ifosfamide, vinblastine, vincristine, procarbazine, dacarbazine, 6-mercaptopurine, methotrexate, 5-f/uor-uracil and adriamycine in a defined experimental model. Varying combinations of drug plus transplantation alloantigen, (C3H-lymphocytes) were injected into Balb/c mice at different time intervals in vivo. The resulting T-effector cell reactivity was determined in vitro with the microcytotoxicity assay on day + 5 for primary (r) and day + 7 for secondary (2°) sensitized mice. According to the type of drug (alkylating agent vs. vinca alkaloid vs. antimetabolite vs. cytostatic antibiotic), the dosage (20\% LD50 vs. 60\% LD50), the state of sensitization (r vs. 2° sensitized recipients), and the time of drug application in relation to the antigen treatment on day 0 (in varying steps from day -6 to day +4), so-called "pharmaconantigen- variation-effects" (PA VE) were established for each of the investigated drugs in form of reaction profiles. The results were as folIows: (1) For almost alt substances, characteristic reaction profiles involving immunostimulation and/or immunosuppression could be established. Similarities in the profiles of different substances made it possible to classify the drugs according to different reaction types. The reaction type however is not definitely correlated to the biochemical mechanism of drug action. (2) The PA VE are decisively inf/uenced by so me of the biological parameters, such as the time of drug application in relation to the antigen treatment and the state of sensitization but relatively !ittle by the dosage of the drug. (3) Considering the different processes occurring du ring primary and secondary immune responses, the PAVE may give hints for a distinct manipulation of the immunoregulation and thus information on the immunobiological mechanism of drug action.}, subject = {Immunologie}, language = {en} } @article{UlrichsKellerMuellerRuchholtz1985, author = {Ulrichs, Karin and Keller, R. and M{\"u}ller-Ruchholtz, W.}, title = {Serological demonstration and manipulation of passenger cells (PC) in pancreas islet grafts}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72944}, year = {1985}, abstract = {No abstract available}, subject = {Immunobiologie}, language = {en} } @article{UlrichsMuellerRuchholtz1985, author = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {Further Analyses of Pancreas Islet Immunogenicity, a Major Barrier to Successful Islet Transplantation}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45563}, year = {1985}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @article{LausUlrichsMuellerRuchholtz1986, author = {Laus, R. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {Molecular Specificity of Human Heterophile Antibodies (HHA) in Normal Human Serum (NHS) Reacting with Xenogeneic Cells.}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72921}, year = {1986}, abstract = {No abstract available}, subject = {Immunobiologie}, language = {en} } @article{UlrichsKellerMuellerRuchholtz1986, author = {Ulrichs, Karin and Keller, R. and M{\"u}ller-Ruchholtz, W.}, title = {Vorkommen und Manipulation von MHC Klasse II Antigenen auf Zellen isolierter Langerhans-Inseln}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45499}, year = {1986}, abstract = {No abstract available}, subject = {Langerhans-Inseln}, language = {de} } @article{KekowUlrichsMuellerRuchholtzetal.1987, author = {Kekow, J. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W. and Gross, WL}, title = {Pancreas transplantation: a study of insulin secretion in isolated islets of Langerhans and in sera using a new enzyme-linked immunosorbent assay}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45229}, year = {1987}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} }