@article{BrandForsterBoecketal.2022, author = {Brand, Jessica S. and Forster, Leonard and B{\"o}ck, Thomas and Stahlhut, Philipp and Teßmar, J{\"o}rg and Groll, J{\"u}rgen and Albrecht, Krystyna}, title = {Covalently Cross-Linked Pig Gastric Mucin Hydrogels Prepared by Radical-Based Chain-Growth and Thiol-ene Mechanisms}, series = {Macromolecular Bioscience}, volume = {22}, journal = {Macromolecular Bioscience}, number = {4}, doi = {10.1002/mabi.202100274}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-318453}, year = {2022}, abstract = {Mucin, a high molecular mass hydrophilic glycoprotein, is the main component of mucus that coats every wet epithelium in animals. It is thus intrinsically biocompatible, and with its protein backbone and the o-glycosidic bound oligosaccharides, it contains a plethora of functional groups which can be used for further chemical modifications. Here, chain-growth and step-growth (thiol-ene) free-radical cross-linked hydrogels prepared from commercially available pig gastric mucin (PGM) are introduced and compared as cost-efficient and easily accessible alternative to the more broadly applied bovine submaxillary gland mucin. For this, PGM is functionalized with photoreactive acrylate groups or allyl ether moieties, respectively. Whereas homopolymerization of acrylate-functionalized polymers is performed, for thiol-ene cross-linking, the allyl-ether-functionalized PGM is cross-linked with thiol-functionalized hyaluronic acid. Morphology, mechanical properties, and cell compatibility of both kinds of PGM hydrogels are characterized and compared. Furthermore, the biocompatibility of these hydrogels can be evaluated in cell culture experiments.}, language = {en} } @article{HorvatVogelKampfetal.2020, author = {Horvat, Sonja and Vogel, Patrick and Kampf, Thomas and Brandl, Andreas and Alshamsan, Aws and Alhadlaq, Hisham A. and Ahamed, Maqusood and Albrecht, Krystyna and Behr, Volker C. and Beilhack, Andreas and Groll, J{\"u}rgen}, title = {Crosslinked Coating Improves the Signal-to-Noise Ratio of Iron Oxide Nanoparticles in Magnetic Particle Imaging (MPI)}, series = {ChemNanoMat}, volume = {6}, journal = {ChemNanoMat}, number = {5}, doi = {10.1002/cnma.202000009}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-214718}, pages = {755 -- 758}, year = {2020}, abstract = {Magnetic particle imaging is an emerging tomographic method used for evaluation of the spatial distribution of iron-oxide nanoparticles. In this work, the effect of the polymer coating on the response of particles was studied. Particles with covalently crosslinked coating showed improved signal and image resolution.}, language = {en} }