@article{SteinmannCortegosoValdiviaNowaketal.2022,
  author    = {Steinmann, Rebekka and Cortegoso Valdivia, Pablo and Nowak, Tanja and Koulaouzidis, Anastasios},
  title     = {An overview of the evolution of capsule endoscopy research — text-mining analysis and publication trends},
  series = {Diagnostics},
  volume    = {12},
  journal   = {Diagnostics},
  number    = {9},
  issn      = {2075-4418},
  doi       = {10.3390/diagnostics12092238},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-288515},
  year      = {2022},
  abstract  = {There has been a steady increase (annual percentage growth rate of 19.2\%, average of 18.3 citations per document) in capsule endoscopy (CE) publications from a global, interdisciplinary research community on a growing range of CE applications over the last 20+ years. We here present the status of CE as a field of research, tracing its evolution over time and providing insight into its potential for diagnostics, prevention and treatment of gastrointestinal (GI) tract diseases. To portray the development of the CE research landscape in the 2000-2021 time span, we analyzed 5764 scientific publications. Analyses were performed using the R language and environment for statistical computing and graphics and VOSviewer, a software developed for scientific literature analysis by scientometricians. The aim of this paper is to provide a wide comprehensive analysis of the trends in CE publications. We thus performed subgroup analysis on the selected papers, including indications, annual percentage growth rate, average citations per document, most publications from research areas/interdisciplinary field of the articles, geography, collaboration networks through institutions, specific clinical keywords and device type. The firm increase in CE publications over the last two decades highlights the overall strength of the technology in GI applications. Furthermore, the introduction to the field of artificial intelligence (AI) tools has been promoting a range of technological advances that keep on affecting the diagnostic potential of CE.},
  language  = {en}
}
@phdthesis{Niederlechner2013,
  author    = {Niederlechner, Stefanie},
  title     = {Assessment of the basic molecular mechanisms underlying L-glutamine's cytoprotective effects after intestinal injury},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-77399},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2013},
  abstract  = {Critical illness like sepsis, shock, and intestinal bowel disease are one of the leading causes of morbidity and mortality in the US and around the world. At present, studies to define new therapeutic interventions that can protect tissues and cells against injury and attenuate inflammation are fields of intense investigation. While research over the past decade has clearly identified GLN as a vital stress substrate facilitating cellular survival following injury, the initiation steps in GLN's cytoprotective molecular mechanism still remain elusive. Previously published work suggested that stabilization of ECM proteins and activation of ECM receptor osmosignaling may play a central role in the orchestration of many cellular pathways following stress. Thus, I hypothesized that preservation of ECM protein and EGFR levels as well as ECM receptor signaling play key roles in the molecular mechanisms underlying GLN's protection against thermal injury in the intestine. I was able to confirm via Western blotting and by using silencing RNA against FN, Ntn-1, EGFR, and their negative controls, that GLN-mediated preservation of FN, Ntn-1, and EGFR levels is critical in GLN's protection against hyperthermia in IEC-6 cells. By using a selective FN-Integrin interaction inhibitor GRGDSP, its negative control peptide GRGESP, and Src-kinase inhibitor PP2, I showed that FN-Integrin signaling and Src-kinase activation are essential in GLN-mediated protection in the intestine. This applied to EGFR signaling as demonstrated using the EGFR tyrosine kinase inhibitor AG1478. In addition to GRGDSP and AG1478, ERK1/2 inhibitors PD98059 and UO126 as well as the p38MAPK inhibitor SB203580 revealed that GLN is protective by activating ERK1/2 and dephosphorylating p38MAPK via FN-Integrin and EGFR signaling. However, GLN-mediated PI3-K/Akt/Hsp70 activation seems to occur independently of FN-Integrin and EGFR signaling as indicated by Western blots as well as experiments using the PI3-K inhibitor LY294002, GRGDSP, and AG1478. The results showed that GLN activates cell survival signaling pathways via integrins as well as EGFRs after hyperthermia. Moreover, I found that GLN-mediated preservation of FN expression after HS is regulated via PI3-K signaling. Whether GLN-mediated PI3-K signaling happens simultaneously to FN-Integrin and EGFR signaling or whether PI3-K signaling coordinates FN-Integrin and EGFR signaling needs to be investigated in future studies. Further, experiments with PD98059 and GRGDSP revealed that ERK1/2 assists in mediating transactivation of HSF-1 following HS. This leads to increases in Hsp70 expression via FN-Integrin signaling, which is known to attenuate apoptosis after thermal injury. Fluorescence microscopy results indicated that HS and GLN regulate cell are size changes and the morphology of F-actin via FN-Integrin signaling. Experiments using GRGDSP and GRGESP showed that GLN enhances cellular survival via FN-Integrin signaling in a manner that does not require increased intracellular GLN concentrations (as quantified using LC-MS/MS). In summary, my thesis work gives new and potentially clinically relevant mechanistic insights into GLN-mediated molecular cell survival pathways. These results warrant clinical translation to assess if clinical outcome of critically ill patients suffering from gastrointestinal diseases can be improved by GLN treatment and/or by targeting the molecular pathways found in my studies.},
  subject      = {Glutamin},
  language  = {en}
}
@misc{OPUS4-4319,
  title     = {Blick - das Magazin der Julius-Maximilians-Universit{\"a}t W{\"u}rzburg. Ausgabe 1/1993. Schwerpunktthema: Infektionen},
  volume    = {1/1993},
  organization    = {Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44876},
  year      = {1993},
  abstract  = {Inhalts{\"u}bersicht zum Schwerpunktthema: - Zentrum zur Erforschung von Infektionskrankheiten - "Virulenzgene" von Bakterien - Molekulare Grundlagen zum Verst{\"a}ndnis bakterieller Infektionen - Der Darm des Menschen: Eintrittspforte und Quelle f{\"u}r Infektionserreger - Unser Immunsystem: Antwort auf die mikrobielle Herausforderung - Neurologische Klinik: Im Zentrum des Interesses stehen Autoimmunerkrankungen - Entstehung und Abwehr von viralen Infektionskrankheiten - Infektionen bei neuropenischen Patienten: Neue Entwicklungen in der Therapie und bei der Erregertypisierung - Probleme bei Therapie und Prophylaxe an Patienten mit HIV -Infektion u. a.},
  subject      = {W{\"u}rzburg},
  language  = {de}
}
@misc{OPUS4-4322,
  title     = {Blick - das Magazin der Julius-Maximilians-Universit{\"a}t W{\"u}rzburg. Ausgabe 1/1994. Schwerpunktthema: Biomedizinische Grundlagenforschung},
  volume    = {1/1994},
  organization    = {Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44891},
  year      = {1994},
  abstract  = {Inhalts{\"u}bersicht zum Schwerpunktthema: - Die Zelle: Signale, Membranen und Molek{\"u}le - Charakterisierung der Durchl{\"a}ssigkeit von Membranfiltern - Kernporen: Transportkan{\"a}le f{\"u}r den Kern-Cytoplasma Austausch - Zelltransformation: Verlust der Ordnung - G-Proteine: Zentrale Schaltstellen f{\"u}r Wirkungen von Hormonen und Arzneimitteln - Beteiligung genetischer Faktoren an Tumorprozessen - Wachstum und Anpassung von Pflanzen u.a.},
  subject      = {W{\"u}rzburg},
  language  = {de}
}
@misc{OPUS4-4324,
  title     = {Blick - das Magazin der Julius-Maximilians-Universit{\"a}t W{\"u}rzburg. Ausgabe 1/1995. Schwerpunktthema: Molekulare Mechanismen der Krebsentstehung},
  volume    = {1/1995},
  organization    = {Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44910},
  year      = {1995},
  abstract  = {Inhalts{\"u}bersicht zum Schwerpunktthema: - Molekulare Mechanismen der Krebsentstehung - Reaktiver Sauerstoff in der Krebsentstehung und Krebstherapie - Krebsentstehung durch Stoffwechselprodukte - Von der Krebsausl{\"o}sung zum Krebswachstum - Zytogenetische Ver{\"a}nderungen bei malignen Lymphomen - Krebs, ein Problem der Deregulierung der Zellteilungskontrolle - Krebstherapie mit Topoisomerase-Inhibitoren u.a.},
  subject      = {W{\"u}rzburg},
  language  = {de}
}
@misc{OPUS4-4326,
  title     = {Blick - das Magazin der Julius-Maximilians-Universit{\"a}t W{\"u}rzburg. Ausgabe 1/1996. Schwerpunktthema: {\"O}kologie, Physiologie und Biochemie pflanzlicher und tierischer Leistung unter Streß},
  volume    = {1/1996},
  organization    = {Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44939},
  year      = {1996},
  abstract  = {Inhalts{\"u}bersicht zum Schwerpunktthema: - Stress und Stressanpassung bei Pflanzen und Tieren - Biologisch aktive Naturstoffe aus tropischen Lianen - Blattschneiderameisen: Dominante Herbivoren in neotropischen Regenw{\"a}ldern - Photosynthese von Gesteinsflechten unter extremen Bedingungen - Chemische Kriegsf{\"u}hrung bei Flechten und Schwammen - Wie sich Pflanzen vor Austrocknung schlitzen - Großer Lauschangriff auf die Photosynthese der Pflanzen u.a.},
  subject      = {W{\"u}rzburg},
  language  = {de}
}
@misc{OPUS4-4368,
  title     = {Blick - das Magazin der Julius-Maximilians-Universit{\"a}t W{\"u}rzburg. Ausgabe 1/1997. Schwerpunktthema: Entwicklung und Manipulation pluripotenter Zellen},
  volume    = {1/1997},
  organization    = {Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44952},
  year      = {1997},
  abstract  = {Inhalts{\"u}bersicht zum Schwerpunktthema: - Gef{\"a}ßkrankheiten und fehlgesteuerte Immunreaktionen - Dendritische Zellen - "Z{\"u}ndfunken" der Immunantwort - Wenn Immunzellen einfach "abschalten" - Tumor-Wirt-Interaktion und ihre Beeinflussung - Immunologische Mißverst{\"a}ndnisse mit katastrophalen Folgen - Moderne Transplantationsforschung - Biochemische Parameter der Endothelfunktion - {\"O}strogene: Mehr als nur Sexualhormone - Herzdiagnostik auf neuen Wegen u.a.},
  subject      = {W{\"u}rzburg},
  language  = {de}
}
@misc{OPUS4-4634,
  title     = {Blick - das Magazin der Julius-Maximilians-Universit{\"a}t W{\"u}rzburg. Ausgabe 1/1998. Schwerpunktthema: Neue Bauelemente f{\"u}r die Informationstechnik (FOROPTO)},
  volume    = {1/1998},
  organization    = {Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44974},
  year      = {1998},
  abstract  = {Inhalts{\"u}bersicht zum Schwerpunktthema: - Von Leuchtdioden und Laser-Fernsehen - Blaues und gr{\"u}nes Laserlicht aus winzigen Kristallen - Technisches Licht aus ultrad{\"u}nnen Molek{\"u}lschichten - Implantat und K{\"o}rper m{\"u}ssen harmonieren u.a.},
  subject      = {W{\"u}rzburg},
  language  = {de}
}
@misc{OPUS4-4636,
  title     = {Blick - das Magazin der Julius-Maximilians-Universit{\"a}t W{\"u}rzburg. Ausgabe 1/1999. Schwerpunktthema: Interdisziplin{\"a}res Tumorzentrum W{\"u}rzburg},
  volume    = {1/1999},
  organization    = {Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44999},
  year      = {1999},
  abstract  = {Inhalts{\"u}bersicht zum Schwerpunktthema: - Erkennung, Therapie und Nachsorge von Tumoren - Tumorkonforme Strahlentherapie - Kinder mit Hirntumoren - Autologe Transplantation von Blutstammzellen - Tumorimmunit{\"a}t am Beispiel des malignen Melanoms - Immuntherapie: ein Antik{\"o}rper gegen Magenkrebs - Brustkrebs - die Lymphknoten und der Einfluss der Gene - Krebs in der unteren Speiser{\"o}hre u.a.},
  subject      = {W{\"u}rzburg},
  language  = {de}
}
@misc{OPUS4-4782,
  title     = {Blick - das Magazin der Julius-Maximilians-Universit{\"a}t W{\"u}rzburg. Ausgabe 1/2000. Schwerpunktthema: Molekulare Grundlagen der Signal{\"u}bertragung und des Stofftransportes in Membranen},
  volume    = {1/2000},
  organization    = {Julius-Maximilians-Universit{\"a}t W{\"u}rzburg},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45018},
  year      = {2000},
  abstract  = {Inhalts{\"u}bersicht zum Schwerpunktthema: - Signale, Routen, Netzwerke: Die Welt der Zelle und ihrer Nachbarn - Kernporen: einfaches Sieb oder schlaue Barriere? - Ionen-Austauscher der Niere verhindert {\"U}bers{\"a}uerung des Blutes - Bakterieller Giftstoff f{\"u}hrte zu neuem Impfkonzept - Pflanzenforschung auf dem Weg vom Molek{\"u}l zur Anwendung - Cytokine instruieren Zellen mit Hilfe von molekularen Eilboten - Regulation der Zellbeweglichkeit und der Blutpl{\"a}ttchen durch VASP u.a.},
  subject      = {W{\"u}rzburg},
  language  = {de}
}