@article{ChenReiherHermannLuibletal.2016,
  author    = {Chen, Jiangtian and Reiher, Wencke and Hermann-Luibl, Christiane and Sellami, Azza and Cognigni, Paola and Kondo, Shu and Helfrich-F{\"o}rster, Charlotte and Veenstra, Jan A. and Wegener, Christian},
  title     = {Allatostatin A Signalling in Drosophila Regulates Feeding and Sleep and Is Modulated by PDF},
  series = {PLoS Genetics},
  volume    = {12},
  journal   = {PLoS Genetics},
  number    = {9},
  doi       = {10.1371/journal.pgen.1006346},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-178170},
  year      = {2016},
  abstract  = {Feeding and sleep are fundamental behaviours with significant interconnections and cross-modulations. The circadian system and peptidergic signals are important components of this modulation, but still little is known about the mechanisms and networks by which they interact to regulate feeding and sleep. We show that specific thermogenetic activation of peptidergic Allatostatin A (AstA)-expressing PLP neurons and enteroendocrine cells reduces feeding and promotes sleep in the fruit fly Drosophila. The effects of AstA cell activation are mediated by AstA peptides with receptors homolog to galanin receptors subserving similar and apparently conserved functions in vertebrates. We further identify the PLP neurons as a downstream target of the neuropeptide pigment-dispersing factor (PDF), an output factor of the circadian clock. PLP neurons are contacted by PDF-expressing clock neurons, and express a functional PDF receptor demonstrated by cAMP imaging. Silencing of AstA signalling and continuous input to AstA cells by tethered PDF changes the sleep/activity ratio in opposite directions but does not affect rhythmicity. Taken together, our results suggest that pleiotropic AstA signalling by a distinct neuronal and enteroendocrine AstA cell subset adapts the fly to a digestive energy-saving state which can be modulated by PDF.},
  language  = {en}
}
@article{HaringWylervonBallmoosAppeletal.2014,
  author    = {Haring, Bernhard and Wyler von Ballmoos, Moritz C. and Appel, Lawrence J. and Sacks, Frank M.},
  title     = {Healthy Dietary Interventions and Lipoprotein (a) Plasma Levels: Results from the Omni Heart Trial},
  doi       = {10.1371/journal.pone.0114859},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-111005},
  year      = {2014},
  abstract  = {Background: Increased lipoprotein(a) [Lp(a)] levels are associated with atherosclerotic cardiovascular disease. Studies of dietary interventions on changes in Lp(a) are sparse. We aimed to compare the effects of three healthy dietary interventions differing in macronutrient content on Lp(a) concentration. Methods: Secondary analysis of a randomized, 3-period crossover feeding study including 155 (89 blacks; 66 whites) individuals. Participants were given DASHtype healthy diets rich in carbohydrates [Carb], in protein [Prot] or in unsaturated fat [Unsat Fat] for 6 weeks each. Plasma Lp(a) concentration was assessed at baseline and after each diet. Results: Compared to baseline, all interventional diets increased mean Lp(a) by 2 to 5 mg/dl. Unsat Fat increased Lp(a) less than Prot with a difference of 1.0 mg/dl (95\% CI, -0.5, 2.5; p=0.196) in whites and 3.7 mg/dl (95\% CI, 2.4, 5.0; p<0.001) in blacks (p-value between races=0.008); Unsat Fat increased Lp(a) less than Carb with a difference of 20.6 mg/dl, 95\% CI, -2.1, 0.9; p=0.441) in whites and 21.5 mg/dl (95\% CI, -0.2, -2.8; p=0.021) in blacks (p-value between races=0.354). Prot increased Lp(a) more than Carb with a difference of 0.4 mg/dl (95\% CI, -1.1, 1.9; p=0.597) in whites and 2.2 mg/dl (95\%CI, 0.9, 3.5; p=0.001) in blacks (p-value between races=0.082). Conclusion: Diets high in unsaturated fat increased Lp(a) levels less than diets rich in carbohydrate or protein with greater changes in blacks than whites. Our results suggest that substitutions with dietary mono- and polyunsaturated fatty acids in healthy diets may be preferable over protein or carbohydrates with regards to Lp(a).},
  language  = {en}
}