@article{TackeLangeBentlageetal.1983, author = {Tacke, Reinhold and Lange, Hartwig and Bentlage, Anke and Sheldrick, William S. and Ernst, Ludger}, title = {2.2.5.5-Tetraorganyl-1.4-dioxa-2.5-disilacyclohexane/2,2,5,5-Tetraorganyl-1,4-dioxa-2,5-disilacyclohexanes}, series = {Zeitschrift f{\"u}r Naturforschung B}, volume = {38}, journal = {Zeitschrift f{\"u}r Naturforschung B}, number = {2}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128423}, pages = {190-193}, year = {1983}, abstract = {The 2,2,5,5-tetraorganyl-1,4-dioxa-2,5-disilacyclohexanes 2a-2c were prepared by condensation of the corresponding (hydroxymethyl)diorganylsilanes 1 a-1 c. The constitution of the heterocycles was confirmed by elemental analyses, cryoscopic measurements, mass spectrometry, and NMR-spectroscopic \((^1H, ^{13}C)\) investigations. The molecular structure of 2 b was determined by X-ray diffraction analysis.}, language = {de} } @article{TackeLangeSheldricketal.1983, author = {Tacke, Reinhold and Lange, Hartwig and Sheldrick, William S. and Lambrecht, G{\"u}nter and Moser, Ulrich and Mutschler, Ernst}, title = {Sila-Pharmaka, 31. Mitt. [1] Synthese, Struktur und pharmakologische Eigenschaften von Diphenyl(2-piperidinoethoxymethyl)silanol und seinem Kohlenstoff-Analogon}, series = {Zeitschrift f{\"u}r Naturforschung B}, volume = {38}, journal = {Zeitschrift f{\"u}r Naturforschung B}, number = {6}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128410}, pages = {738-746}, year = {1983}, abstract = {In the course of systematic investigations on sila-substituted parasympatholytics the diphenyl(2-aminoethoxymethyl)silanols 3b and 4b (and its carbon analogue 4a) were synthesized and characterized by their physical and chemical properties. In the solid state 4a and 4b form strong O-H---N hydrogen bonds, which are intramolecular (4a) and intermolecular (4b), respectively. 4a and 4b were found to be weak antimuscarinic agents (4b >4a) and strong papaverine-like spasmolytics (4a ≈4b).}, language = {de} } @article{TackeLinohAttarBashietal.1982, author = {Tacke, Reinhold and Linoh, Haryanto and Attar-Bashi, Moayad T. and Sheldrick, William S. and Ernst, Ludger and Niedner, Roland and Frohnecke, Joachim}, title = {Sila-Pharmaka, 26. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, III}, series = {Zeitschrift f{\"u}r Naturforschung B}, volume = {37}, journal = {Zeitschrift f{\"u}r Naturforschung B}, number = {11}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128402}, pages = {1461-1471}, year = {1982}, abstract = {The potentially curare-like silicon compounds 8a- 8f were synthesized and investigated with respect to their structure-activity relationships. The conformations of the compounds in the solid state and in solution were studied by X-ray diffraction analysis (8a- 8e) and IR NMR spectroscopy (8a- 8f), respectively. The muscle relaxing properties of 8a- 8f were investigated on the mouse. The observed structure-activity relationships are not in accordance with the classical "14 {\AA} model" for neuromuscular blocking agents.}, language = {de} } @article{TackeLinohStumpfetal.1983, author = {Tacke, Reinhold and Linoh, Haryanto and Stumpf, Burghard and Abraham, Wolf-Rainer and Kieslich, Klaus and Ernst, Ludger}, title = {Mikrobiologische Umwandlung von Silicium-Verbindungen: Enantioselektive Reduktion von Acetessigs{\"a}ure-(trimethylsilylalkyl)estern und deren Carba-Analoga}, series = {Zeitschrift f{\"u}r Naturforschung B}, volume = {38}, journal = {Zeitschrift f{\"u}r Naturforschung B}, number = {5}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128304}, pages = {616-620}, year = {1983}, abstract = {The trimethylsilylalkyl acetoacetates 1 b and 2 b as well as their carba analogues 1 a and 2 a have been reduced microbiologically by Kloeckera corticis (ATCC 20109), leading to the corresponding ( + )-3(S)-hydroxybutanoates 3b, 4b, 3a, and 4a. The enantiomeric purity was found to be 80\% (3a, 3b, 4b) and 65\% (4a), respectively. The reduction of lb and 2b is - to our knowledge - the first example for a controlled microbiological transformation of organosilicon substrates.}, language = {de} } @article{TackeLinkBentlageFeltenetal.1985, author = {Tacke, Reinhold and Link, Matthias and Bentlage-Felten, Anke and Zilch, Harald}, title = {Zum thermischen Verhalten einiger Kohlens{\"a}ure[(methylphenylsilyl)methyl]ester-Derivate}, series = {Zeitschrift f{\"u}r Naturforschung B}, volume = {40}, journal = {Zeitschrift f{\"u}r Naturforschung B}, number = {7}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128293}, pages = {942-947}, year = {1985}, abstract = {The synthesis and the thermal behaviour of the (methylphenylsilyl)methyl carbonates \(CH_3(C_6H_5)Si(H)CH_2OC(O)X (6: X = OCH_3; 7: X = Cl; 8: X = N(CH_3)_2)\) is described. 8 rearranges in toluene solution at 100 °C quantitatively to give the carbam oyloxysilane \(C_6H_5(CH_3)_2SiOC(O)N(CH_3)_2\) (11), whereas neat 6 and 7 at 135 °C undergo quantitative formation of \(C_6H_5(CH_3)_2SiOCH_3\) (12) and \(C_6H_5(CH_3)_2SiCl\) (13), respectively. The formation of 12 and 13 is explained by a rearrangement reaction (by analogy to the rearrangement of 8), follow ed by a decarboxylation. The thermally induced transformations 6 →12, 7 →13, and 8 →11 were found to be first-order reactions with half-lifes of ~2.6 h (135 °C, neat), ~4.5 h (135 °C, neat), and ~3.7 h (100 °C, in toluene), respectively.}, language = {de} } @article{TackeNiederer1978, author = {Tacke, Reinhold and Niederer, Reinhold}, title = {Sila-Pharmaka, 9. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, I}, series = {Zeitschrift f{\"u}r Naturforschung B}, volume = {33}, journal = {Zeitschrift f{\"u}r Naturforschung B}, number = {4}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128277}, pages = {412-416}, year = {1978}, abstract = {Organosilicon compounds 8, 9 and 10 with potential curare-like action and their precursors 0, 6 and 7 were synthesized for the first time. 0-10 were characterized by their physical and chemical properties, and their structures were confirmed by analyses, IH NMR and mass spectroscopy (only for 0-7). The pharmacological and toxicological data of 8, 9 and 10 are reported.}, language = {de} } @article{SaadTacke1977, author = {Saad, S. M. and Tacke, Reinhold}, title = {Zur Darstellung von 1,1,3,3-Tetramethyl-1,3-disila-2,4,7-trioxa-cycloheptan (1) und 1,1,3,3-Tetramethyl-1,3-disila-2,4,8-trioxa-cyclooctan (2)}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86958}, year = {1977}, abstract = {No abstract available.}, subject = {Anorganische Analyse}, language = {de} } @article{TackeBentlageFeltenLinohetal.1986, author = {Tacke, Reinhold and Bentlage-Felten, Anke and Linoh, Haryanto and Magda, Stephen}, title = {Sila-Analoga des Triparanols und Ethamoxytriphetols: Synthese sowie pharmakologische und toxikologische Eigenschaften}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86940}, year = {1986}, abstract = {No abstract available.}, language = {de} } @article{TackeLinkJoppienetal.1986, author = {Tacke, Reinhold and Link, Matthias and Joppien, Hartmut and Ernst, Ludger}, title = {Sila-Substitution des Akarizids Fenbutatinoxid und einiger seiner Derivate: Synthese und Eigenschaften von Hexakis[(dimethylphenylsilyl)methyl]distannoxan und Tris[(dimethylphenylsilyl)methyl](1,2,4-triazol-1-yl)stannan}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86937}, year = {1986}, abstract = {No abstract available.}, subject = {Chemische Synthese}, language = {de} } @article{TackeWiesenberger1991, author = {Tacke, Reinhold and Wiesenberger, Frank}, title = {(Acetoxymethyl)methylphenylgerman: Synthese, thermisches Verhalten und olfaktorische Eigenschaften}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86927}, year = {1991}, abstract = {No abstract available.}, subject = {Chemische Synthese}, language = {de} }