@article{TackeLangeSheldricketal.1983, author = {Tacke, Reinhold and Lange, Hartwig and Sheldrick, William S. and Lambrecht, G{\"u}nter and Moser, Ulrich and Mutschler, Ernst}, title = {Sila-Pharmaka, 31. Mitt. [1] Synthese, Struktur und pharmakologische Eigenschaften von Diphenyl(2-piperidinoethoxymethyl)silanol und seinem Kohlenstoff-Analogon}, series = {Zeitschrift f{\"u}r Naturforschung B}, volume = {38}, journal = {Zeitschrift f{\"u}r Naturforschung B}, number = {6}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128410}, pages = {738-746}, year = {1983}, abstract = {In the course of systematic investigations on sila-substituted parasympatholytics the diphenyl(2-aminoethoxymethyl)silanols 3b and 4b (and its carbon analogue 4a) were synthesized and characterized by their physical and chemical properties. In the solid state 4a and 4b form strong O-H---N hydrogen bonds, which are intramolecular (4a) and intermolecular (4b), respectively. 4a and 4b were found to be weak antimuscarinic agents (4b >4a) and strong papaverine-like spasmolytics (4a ≈4b).}, language = {de} }