@article{LuleKueblerLudolph2019,
  author    = {Lul{\´e}, Doroth{\´e}e and K{\"u}bler, Andrea and Ludolph, Albert C.},
  title     = {Ethical principles in patient-centered medical care to support quality of life in amyotrophic lateral sclerosis},
  series = {Frontiers in Neurology},
  volume    = {10},
  journal   = {Frontiers in Neurology},
  issn      = {1664-2295},
  doi       = {10.3389/fneur.2019.00259},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-196239},
  year      = {2019},
  abstract  = {It is one of the primary goals of medical care to secure good quality of life (QoL) while prolonging survival. This is a major challenge in severe medical conditions with a prognosis such as amyotrophic lateral sclerosis (ALS). Further, the definition of QoL and the question whether survival in this severe condition is compatible with a good QoL is a matter of subjective and culture-specific debate. Some people without neurodegenerative conditions believe that physical decline is incompatible with satisfactory QoL. Current data provide extensive evidence that psychosocial adaptation in ALS is possible, indicated by a satisfactory QoL. Thus, there is no fatalistic link of loss of QoL when physical health declines. There are intrinsic and extrinsic factors that have been shown to successfully facilitate and secure QoL in ALS which will be reviewed in the following article following the four ethical principles (1) Beneficence, (2) Non-maleficence, (3) Autonomy and (4) Justice, which are regarded as key elements of patient centered medical care according to Beauchamp and Childress. This is a JPND-funded work to summarize findings of the project NEEDSinALS (www.NEEDSinALS.com) which highlights subjective perspectives and preferences in medical decision making in ALS.},
  language  = {en}
}
@article{PaeleckeHabermannPaeleckeMauthetal.2019,
  author    = {Paelecke-Habermann, Yvonne and Paelecke, Marko and Mauth, Juliane and Tschisgale, Juliane and Lindenmeyer, Johannes and K{\"u}bler, Andrea},
  title     = {A comparison of implicit and explicit reward learning in low risk alcohol users versus people who binge drink and people with alcohol dependence},
  series = {Addictive Behaviors Reports},
  volume    = {9},
  journal   = {Addictive Behaviors Reports},
  doi       = {10.1016/j.abrep.2019.100178},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-201406},
  pages     = {100178},
  year      = {2019},
  abstract  = {Chronic alcohol use leads to specific neurobiological alterations in the dopaminergic brain reward system, which probably are leading to a reward deficiency syndrome in alcohol dependence. The purpose of our study was to examine the effects of such hypothesized neurobiological alterations on the behavioral level, and more precisely on the implicit and explicit reward learning. Alcohol users were classified as dependent drinkers (using the DSM-IV criteria), binge drinkers (using criteria of the USA National Institute on Alcohol Abuse and Alcoholism) or low-risk drinkers (following recommendations of the Scientific board of trustees of the German Health Ministry). The final sample (n = 94) consisted of 36 low-risk alcohol users, 37 binge drinkers and 21 abstinent alcohol dependent patients. Participants were administered a probabilistic implicit reward learning task and an explicit reward- and punishment-based trial-and-error-learning task. Alcohol dependent patients showed a lower performance in implicit and explicit reward learning than low risk drinkers. Binge drinkers learned less than low-risk drinkers in the implicit learning task. The results support the assumption that binge drinking and alcohol dependence are related to a chronic reward deficit. Binge drinking accompanied by implicit reward learning deficits could increase the risk for the development of an alcohol dependence.},
  language  = {en}
}