@article{DomschkeZwanzgerRehbeinetal.2016,
  author    = {Domschke, Katharina and Zwanzger, Peter and Rehbein, Maimu A. and Steinberg, Christian and Knoke, Kathrin and Dobel, Christian and Klinkenberg, Isabelle and Kugel, Harald and Kersting, Anette and Arolt, Volker and Pantev, Christo and Junghofer, Markus},
  title     = {Magnetoencephalographic Correlates of Emotional Processing in Major Depression Before and After Pharmacological Treatment},
  series = {International Journal of Neuropsychopharmacology},
  volume    = {2016},
  journal   = {International Journal of Neuropsychopharmacology},
  doi       = {10.1093/ijnp/pyv093},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-165523},
  pages     = {1-9},
  year      = {2016},
  abstract  = {Background: In major depressive disorder (MDD), electrophysiological and imaging studies suggest reduced neural activity in the parietal and dorsolateral prefrontal cortex regions. In the present study, neural correlates of emotional processing in MDD were analyzed for the first time in a pre-/post-treatment design by means of magnetoencephalography (MEG), allowing for detecting temporal dynamics of brain activation. Methods: Twenty-five medication-free Caucasian in-patients with MDD and 25 matched controls underwent a baseline MEG session with passive viewing of pleasant, unpleasant, and neutral pictures. Fifteen patients were followed-up with a second MEG session after 4 weeks of antidepressant monopharmacotherapy with mirtazapine. The corresponding controls received no intervention between the measurements. The clinical course of depression was assessed using the Hamilton Depression scale. Results: Prior to treatment, an overall neocortical hypoactivation during emotional processing, particularly at the parietal regions and areas at the right temporoparietal junction, as well as abnormal valence-specific reactions at the right parietal and bilateral dorsolateral prefrontal cortex (dlPFC) regions were observed in patients compared to controls. These effects occurred <150ms, suggesting dysfunctional processing of emotional stimuli at a preconscious level. Successful antidepressant treatment resulted in a normalization of the hypoactivation at the right parietal and right temporoparietal regions. Accordingly, both dlPFC regions revealed an increase of activity after therapy. Conclusions: The present study provides neurophysiological evidence for dysfunctional emotional processing in a fronto-parieto-temporal network, possibly contributing to the pathogenesis of MDD. These activation patterns might have the potential to serve as biomarkers of treatment success.},
  language  = {en}
}
@article{DomschkeZwanzgerRehbeinetal.2016,
  author    = {Domschke, Katharina and Zwanzger, Peter and Rehbein, Maimu A and Steinberg, Christian and Knoke, Kathrin and Dobel, Christian and Klinkenberg, Isabelle and Kugel, Harald and Kersting, Anette and Arolt, Volker and Pantev, Christo and Junghofer, Markus},
  title     = {Magnetoencephalographic correlates of emotional processing in major depression before and after pharmacological treatment},
  series = {International Journal of Neuropsychopharmacology},
  volume    = {19},
  journal   = {International Journal of Neuropsychopharmacology},
  number    = {2},
  doi       = {10.1093/ijnp/pyv093},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-149873},
  pages     = {pyv093},
  year      = {2016},
  abstract  = {Background: In major depressive disorder (MDD), electrophysiological and imaging studies suggest reduced neural activity in the parietal and dorsolateral prefrontal cortex regions. In the present study, neural correlates of emotional processing in MDD were analyzed for the first time in a pre-/post-treatment design by means of magnetoencephalography (MEG), allowing for detecting temporal dynamics of brain activation. Methods: Twenty-five medication-free Caucasian in-patients with MDD and 25 matched controls underwent a baseline MEG session with passive viewing of pleasant, unpleasant, and neutral pictures. Fifteen patients were followed-up with a second MEG session after 4 weeks of antidepressant monopharmacotherapy with mirtazapine. The corresponding controls received no intervention between the measurements. The clinical course of depression was assessed using the Hamilton Depression scale. Results: Prior to treatment, an overall neocortical hypoactivation during emotional processing, particularly at the parietal regions and areas at the right temporoparietal junction, as well as abnormal valence-specific reactions at the right parietal and bilateral dorsolateral prefrontal cortex (dlPFC) regions were observed in patients compared to controls. These effects occurred <150ms, suggesting dysfunctional processing of emotional stimuli at a preconscious level. Successful antidepressant treatment resulted in a normalization of the hypoactivation at the right parietal and right temporoparietal regions. Accordingly, both dlPFC regions revealed an increase of activity after therapy. Conclusions: The present study provides neurophysiological evidence for dysfunctional emotional processing in a fronto-parieto-temporal network, possibly contributing to the pathogenesis of MDD. These activation patterns might have the potential to serve as biomarkers of treatment success.},
  language  = {en}
}
@article{BremGruenblattDrechsleretal.2014,
  author    = {Brem, Silvia and Gr{\"u}nblatt, Edna and Drechsler, Renate and Riederer, Peter and Walitza, Susanne},
  title     = {The neurobiological link between OCD and ADHD},
  series = {Attention Deficit and Hyperactivity Disorders},
  volume    = {6},
  journal   = {Attention Deficit and Hyperactivity Disorders},
  number    = {3},
  doi       = {10.1007/s12402-014-0146-x},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-121312},
  pages     = {175-202},
  year      = {2014},
  abstract  = {Obsessive compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD) are two of the most common neuropsychiatric diseases in paediatric populations. The high comorbidity of ADHD and OCD with each other, especially of ADHD in paediatric OCD, is well described. OCD and ADHD often follow a chronic course with persistent rates of at least 40-50 \%. Family studies showed high heritability in ADHD and OCD, and some genetic findings showed similar variants for both disorders of the same pathogenetic mechanisms, whereas other genetic findings may differentiate between ADHD and OCD. Neuropsychological and neuroimaging studies suggest that partly similar executive functions are affected in both disorders. The deficits in the corresponding brain networks may be responsible for the perseverative, compulsive symptoms in OCD but also for the disinhibited and impulsive symptoms characterizing ADHD. This article reviews the current literature of neuroimaging, neurochemical circuitry, neuropsychological and genetic findings considering similarities as well as differences between OCD and ADHD.},
  language  = {en}
}
@phdthesis{Wagener2005,
  author    = {Wagener, Annika},
  title     = {The NoGo-anteriorization and its relation to a central inhibitory mechanism},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-14799},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2005},
  abstract  = {The maximum of the brain electrical field after NoGo stimuli is located more anteriorly than that after stimuli that tells participants to respond. The difference in topography was called NoGo-Anteriorization (NGA). Recently, there was a debate, whether the NGA is related to a central inhibitory process or not. However, experiments showed that the NGA is not the result of motor potentials during Go trials, the NGA does not represent higher response conflict and or higher mental effort in NoGo trials, and the NGA is not based on less cognitive response selection in NoGo trials. Therefore, the experiments support the assumption that the NGA is connected to an inhibitory mechanism in NoGo conditions.},
  subject      = {Handlung},
  language  = {en}
}