@phdthesis{Stetter2021,
  author    = {Stetter, Maurice},
  title     = {LC3-associated phagocytosis seals the fate of the second polar body in \(Caenorhabditis\) \(elegans\)},
  doi       = {10.25972/OPUS-23198},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-231981},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2021},
  abstract  = {This work investigates the death and degradation of the second polar body of the nematode C. elegans in order to improve our understanding how pluripotent undifferentiated cells deal with dying cells. With the use of fluorescence microscopy this work demonstrates that both polar bodies loose membrane integrity early. The second polar body has contact to embryonic cells and gets internalized, dependent on the Rac1-ortholog CED-10. The polar body gets degraded via LC3-associated phagocytosis. While lysosome recruitment depends on RAB-7, LC3 does not improve lysosome recruitment but still accelerates polar body degradation. This work establishes the second polar body as a genetic model to study cell death and LC3-associated phagocytosis and has revealed further aspects of phagosome maturation and degradation.},
  subject      = {Polk{\"o}rper},
  language  = {en}
}
@phdthesis{Irmisch2019,
  author    = {Irmisch, Linda},
  title     = {The role of septins and other regulatory proteins in abscission and midbody fate in C. elegans embryos},
  doi       = {10.25972/OPUS-18324},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-183244},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2019},
  abstract  = {Abscission marks the last step of cytokinesis and gives rise to two physically separated daughter cells and a midbody remnant. This work studies abscission by examining the extent of the abscission failure in C. elegans septin and ESCRT mutants with the help of the ZF1-degradation technique. The ZF1 technique is also applied to discern a possible role for PI3K during abscission. Lastly, we test the role of proteins required for macroautophagy but not for LC3-associated phagocytosis (LAP) and show that after release into the extracellular space, the midbody is resolved via LAP.},
  subject      = {Zellteilung},
  language  = {en}
}