@article{NosterdeKoningMaieretal.2016,
  author    = {Noster, Rebecca and de Koning, Heleen D. and Maier, Elisabeth and Prelog, Martina and Lainka, Elke and Zielinski, Christina E.},
  title     = {Dysregulation of proinflammatory versus anti-inflammatory human T\(_H\)17 cell functionalities in the autoinflammatory Schnitzler syndrome},
  series = {Journal of Allergy and Clinical Immunology},
  volume    = {138},
  journal   = {Journal of Allergy and Clinical Immunology},
  number    = {4},
  doi       = {10.1016/j.jaci.2015.12.1338},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-187205},
  pages     = {1161-1169.e6},
  year      = {2016},
  abstract  = {Background: T\(_H\)17 cells have so far been considered to be crucial mediators of autoimmune inflammation. Two distinct types of T\(_H\)17 cells have been described recently, which differed in their polarization requirement for IL-1b and in their cytokine repertoire. Whether these distinct T\(_H\)17 phenotypes translate into distinct T\(_H\)17 cell functions with implications for human health or disease has not been addressed yet. Objective: We hypothesized the existence of proinflammatory and anti-inflammatory human T\(_H\)17 cell functions based on the differential expression of IL-10, which is regulated by IL-1 beta. Considering the crucial role of IL-1 beta in the pathogenesis of autoinflammatory syndromes, we hypothesized that IL-1 beta mediates the loss of anti-inflammatory T\(_H\)17 cell functionalities in patients with Schnitzler syndrome, an autoinflammatory disease. Methods: To assess proinflammatory versus anti-inflammatory T\(_H\)17 cell functions, we performed suppression assays and tested the effects of IL-1 beta dependent and independent T\(_H\)17 subsets on modulating proinflammatory cytokine secretion by monocytes. Patients with Schnitzler syndrome were analyzed for changes in T\(_H\)17 cell functions before and during therapy with IL-1 beta-blocking drugs. Results: Both T\(_H\)17 cell subsets differ in their ability to suppress T-cell proliferation and their ability to modulate proinflammatory cytokine production by antigen-presenting cells because of their differential IL-10 expression properties. In patients with Schnitzler syndrome, systemic overproduction of IL-1 beta translates into a profound loss of anti-inflammatory T\(_H\)17 cell functionalities, which can be reversed by anti-IL-1b treatment. Conclusion: IL-1 beta signaling determines the differential expression pattern of IL-10, which is necessary and sufficient to induce proinflammatory versus anti-inflammatory T\(_H\)17 cell functions. Our data introduce T\(_H\)17 cell subsets as novel players in autoinflammation and thus novel therapeutic targets in autoinflammatory syndromes including other IL-1 beta mediated diseases. This demonstrates for the first time alterations in the adaptive immune system in patients with autoinflammatory syndromes.},
  language  = {en}
}
@article{OPUS4-22607,
  title     = {Search for heavy resonances decaying to a photon and a hadronically decaying \({Z/W/H}\) boson in \(pp\) collisions at root \(s\)=13 TeV with the ATLAS detector},
  series = {Physical Review D},
  volume    = {98},
  journal   = {Physical Review D},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1103/PhysRevD.98.032015},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-226079},
  pages     = {1-29},
  year      = {2018},
  abstract  = {Many extensions of the Standard Model predict new resonances decaying to a Z, W, or Higgs boson and a photon. This paper presents a search for such resonances produced in pp collisions at root s = 13 TeV using a data set with an integrated luminosity of 36.1 fb(-1) collected by the ATLAS detector at the LHC. The Z/W/H bosons are identified through their decays to hadrons. The data are found to be consistent with the Standard Model expectation in the entire investigated mass range. Upper limits are set on the production cross section times branching fraction for resonance decays to Z.W + gamma in the mass range from 1.0 to 6.8 TeV and for the first time into H + gamma in the mass range from 1.0 to 3.0 TeV.},
  language  = {en}
}