@phdthesis{Krauss2011,
  author    = {Krauss, Eva},
  title     = {Analyse der Expression von MAGE-A-Antigenen in Pr{\"a}kursorl{\"a}sionen und manifesten Tumoren des oralen Plattenepithelkarzinoms},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-66188},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2011},
  abstract  = {Orale Plattenepithelkarzinome entwickeln sich h{\"a}ufig aus Pr{\"a}kanzerosen. Trotz der Fr{\"u}hdiagnostik ist es f{\"u}r den Kliniker und den Pathologen meist schwierig eine Pr{\"a}kanzerose, die zur Entartung neigt, rechtzeitig als solche zu erkennen. MAGE-A-Antigene sind Tumorantigene, die nur in malignen Zellen vorkommen. Diese Antigene k{\"o}nnen dazu dienen, Karzinome fr{\"u}her als solche zu erkennen. Das Ziel dieser Studie war, diese Hypothese zu best{\"a}tigen, indem gutartige, pr{\"a}kanzer{\"o}se und karzinomat{\"o}se Ver{\"a}nderung untersucht wurden. Dazu wurden retrospektiv Biopsien der oralen Schleimhaut (orale Ulzera, Epulitiden, follikul{\"a}re Zysten, Lichen planus, Leukolakien, epitheliale Dysplasien und Carcinomata in situ) untersucht. Diese wurden immunhistochemisch mit dem polyklonalen Antik{\"o}rper MAGE-A 57B angef{\"a}rbt. Dabei stellte sich heraus, dass MAGE-A-Antigene nicht in gutartigen Ver{\"a}nderungen vorkommen, jedoch zu 33-65\% in pr{\"a}kanzer{\"o}sen und malignen L{\"a}sionen. Ein weiteres Ziel umfasste die Untersuchung der kritischen Randbereiche. Hier wurde bei den positv gef{\"a}rbten Pr{\"a}paraten eine eindeutige Grenze zwischen benigner und maligner Schleimhaut durch die Anf{\"a}rbung mit mAb-57B sichtbar.},
  subject      = {Pr{\"a}kanzerose},
  language  = {de}
}
@article{SulimanMustafaKruegeretal.2016,
  author    = {Suliman, Salwa and Mustafa, Kamal and Krueger, Anke and Steinm{\"u}ller-Nethl, Doris and Finne-Wistrand, Anna and Osdal, Tereza and Hamza, Amani O. and Sun, Yang and Parajuli, Himalaya and Waag, Thilo and Nickel, Joachim and Johannessen, Anne Christine and McCormack, Emmet and Costea, Daniela Elena},
  title     = {Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes},
  series = {Biomaterials},
  volume    = {95},
  journal   = {Biomaterials},
  doi       = {10.1016/j.biomaterials.2016.04.002},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-188287},
  pages     = {11-21},
  year      = {2016},
  abstract  = {This study aimed to evaluate the tumorigenic potential of functionalising poly(LLA-co-CL) scaffolds. The copolymer scaffolds were functionalised with nanodiamonds (nDP) or with nDP and physisorbed BMP-2 (nDP-PHY) to enhance osteoinductivity. Culturing early neoplastic dysplastic keratinocytes (DOK\(^{Luc}\)) on nDP modified scaffolds reduced significantly their subsequent sphere formation ability and decreased significantly the cells' proliferation in the supra-basal layers of in vitro 3D oral neoplastic mucosa (3D-OT) when compared to DOK\(^{Luc}\) previously cultured on nDP-PHY scaffolds. Using an in vivo non-invasive environmentally-induced oral carcinogenesis model, nDP scaffolds were observed to reduce bioluminescence intensity of tumours formed by DOK\(^{Luc}\) + carcinoma associated fibroblasts (CAF). nDP modification was also found to promote differentiation of DOK\(^{Luc}\) both in vitro in 3D-OT and in vivo in xenografts formed by DOKLuc alone. The nDP-PHY scaffold had the highest number of invasive tumours formed by DOK\(^{Luc}\) + CAF outside the scaffold area compared to the nDP and control scaffolds. In conclusion, in vitro and in vivo results presented here demonstrate that nDP modified copolymer scaffolds are able to decrease the tumorigenic potential of DOK\(^{Luc}\), while confirming concerns for the therapeutic use of BMP-2 for reconstruction of bone defects in oral cancer patients due to its tumour promoting capabilities.},
  language  = {en}
}