@article{MehnertKochSchulzetal.2012,
  author    = {Mehnert, Anja and Koch, Uwe and Schulz, Holger and Wegscheider, Karl and Weis, Joachim and Faller, Hermann and Keller, Monika and Br{\"a}hler, Elmar and H{\"a}rter, Martin},
  title     = {Prevalence of mental disorders, psychosocial distress and need for psychosocial support in cancer patients - study protocol of an epidemiological multi-center study},
  volume    = {12},
  number    = {70},
  doi       = {10.1186/1471-244X-12-70},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-153296},
  year      = {2012},
  abstract  = {Background Empirical studies investigating the prevalence of mental disorders and psychological distress in cancer patients have gained increasing importance during recent years, particularly with the objective to develop and implement psychosocial interventions within the cancer care system. Primary purpose of this epidemiological cross-sectional multi-center study is to detect the 4-week-, 12-month-, and lifetime prevalence rates of comorbid mental disorders and to further assess psychological distress and psychosocial support needs in cancer patients across all major tumor entities within the in- and outpatient oncological health care and rehabilitation settings in Germany. Methods/Design In this multicenter, epidemiological cross-sectional study, cancer patients across all major tumor entities will be enrolled from acute care hospitals, outpatient cancer care facilities, and rehabilitation centers in five major study centers in Germany: Freiburg, Hamburg, Heidelberg, Leipzig and W{\"u}rzburg. A proportional stratified random sample based on the nationwide incidence of all cancer diagnoses in Germany is used. Patients are consecutively recruited in all centers. On the basis of a depression screener (PHQ-9) 50\% of the participants that score below the cutoff point of 9 and all patients scoring above are assessed using the Composite International Diagnostic Interview for Oncology (CIDI-O). In addition, all patients complete validated questionnaires measuring emotional distress, information and psychosocial support needs as well as quality of life. Discussion Epidemiological data on the prevalence of mental disorders and distress provide detailed and valid information for the estimation of the demands for the type and extent of psychosocial support interventions. The data will provide information about specific demographic, functional, cancer- and treatment-related risk factors for mental comorbidity and psychosocial distress, specific supportive care needs and use of psychosocial support offers.},
  language  = {en}
}
@article{KittelSchneiderKenisScheketal.2012,
  author    = {Kittel-Schneider, Sarah and Kenis, Gunter and Schek, Julia and van den Hove, Daniel and Prickaerts, Jos and Lesch, Klaus-Peter and Steinbusch, Harry and Reif, Andreas},
  title     = {Expression of monoamine transporters, nitric oxide synthase 3, and neurotrophin genes in antidepressant-stimulated astrocytes},
  series = {Frontiers in Psychiatry},
  volume    = {3},
  journal   = {Frontiers in Psychiatry},
  doi       = {10.3389/fpsyt.2012.00033},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-123627},
  pages     = {33},
  year      = {2012},
  abstract  = {Background: There is increasing evidence that glial cells play a role in the pathomechanisms of mood disorders and the mode of action of antidepressant drugs. Methods: To examine whether there is a direct effect on the expression of different genes encoding proteins that have been implicated in the pathophysiology of affective disorders, primary astrocyte cell cultures from rats were treated with two different antidepressant drugs, imipramine and escitalopram, and the RNA expression of brain-derived neurotrophic factor (Bdnf), serotonin transporter (5Htt), dopamine transporter (Dat), and endothelial nitric oxide synthase (Nos3) was examined. Results: Stimulation of astroglial cell culture with imipramine, a tricyclic antidepressant, led to a significant increase of the Bdnf RNA level whereas treatment with escitalopram did not. In contrast, 5Htt was not differentially expressed after antidepressant treatment. Finally, neither Dat nor Nos3 RNA expression was detected in cultured astrocytes. Conclusion: These data provide further evidence for a role of astroglial cells in the molecular mechanisms of action of antidepressants.},
  language  = {en}
}
@phdthesis{Merwart2012,
  author    = {Merwart, Moritz},
  title     = {Die Inanspruchnahme von psychosozialen Unterst{\"u}tzungsangeboten bei Krebskranken - eine geschlechtsspezifische Untersuchung},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-74324},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2012},
  abstract  = {Untersuchung der Inanspruchnahme von psychosozialen Unterst{\"u}tzungsangeboten bei Krebspatienten. In einer multizentrischen Studie wurde untersucht, welche Unterst{\"u}tzungsangebote bevorzugt in Anspruch genommen werden und ob es hinsichtlich der Inanspruchnahme einen Geschlechterunterschied gibt. Außerdem wurden diverse andere Pr{\"a}diktoren untersucht, die einen Einfluss auf die Inanspruchnahme haben k{\"o}nnen (z.B. Depressivit{\"a}t, psychische St{\"o}rung, Alter, Bildungsstand). Zur Datenerhebung dienten Selbstbeurteilungsinstrumente in Form von Frageb{\"o}gen und ein standardisiertes klinisches Interview (CIDI).},
  subject      = {Psychoonkologie},
  language  = {de}
}
@phdthesis{Kunert2012,
  author    = {Kunert, Mario},
  title     = {Angst und Depression in der prim{\"a}r{\"a}rztliche Versorgung},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-74584},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2012},
  abstract  = {Die vorliegende Studie untersucht den Einsatz von Kurz-Screening-Instrumenten (bestehend aus dem PHQ-4, mit seinen beiden Untereinheiten dem GAD-2 und dem PHQ-2) hinsichtlich der Tauglichkeit f{\"u}r einen Routineeinsatz in Hausarztpraxen. Gescreent wurde auf das m{\"o}gliche Vorliegen einer Angst- und/oder depressive St{\"o}rungen mit anschließender Validit{\"a}tspr{\"u}fung einer kleineren Stichprobe. Hinsichtlich der Validit{\"a}tspr{\"u}fung konnte zwischen den CIDI- und den Screening-Ergebnissen eine gute {\"U}bereinstimmung ermittelt werden (prozentuale {\"U}ber-einstimmung von 80,8\% bei einem Cohen-Kappa von 0,62). Insgesamt betrachtet l{\"a}sst sich mit einem vertretbaren Mehrbedarf an Zeit f{\"u}r nicht-{\"a}rztliche Mitarbeiter ein PHQ-4-Screening in einer Hausarztpraxis durchf{\"u}hren. Durch diese Maßnahme k{\"o}nnen - bei gleichzeitiger Entlastung des Arztes - wichtige Informationen f{\"u}r eine Krankheitserkennung und f{\"u}r eine ggf. notwendige Therapie gewonnen werden. {\"U}ber einen Routineeinsatz von Kurz-Screenern in der prim{\"a}r-{\"a}rztlichen Versorgung sollte nachgedacht werden.},
  subject      = {Angst},
  language  = {de}
}