@article{WangLiKateleetal.2014, author = {Wang, Hui and Li, Min-Yi and Katele, F{\´e}lix Zongwe and Satyanandamurty, Tirumani and Wu, Jun and Bringmann, Gerhard}, title = {Decandrinin, an unprecedented \(C_9\)-spiro-fused 7,8-\( seco-ent\)-abietane from the Godavari mangrove \(Ceriops\ decandra\)}, series = {Beilstein Journal of Organic Chemistry}, volume = {10}, journal = {Beilstein Journal of Organic Chemistry}, issn = {1860-5397}, doi = {10.3762/bjoc.10.23}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-119983}, pages = {276-81}, year = {2014}, abstract = {Decandrinin (1), an unprecedented \(C_9\)-spiro-fused 7,8-\(seco-ent\)-abietane, was obtained from the bark of an Indian mangrove, \(Ceriops\ decandra\), collected in the estuary of Godavari, Andhra Pradesh. The constitution and the relative configuration of 1 were determined by HRMS (ESI) and extensive NMR investigations, and the absolute configuration by circular dichroism (CD) and optical-rotatory dispersion (ORD) spectroscopy in combination with quantum-chemical calculations. Decandrinin is the first 7,8-\(seco-ent\)-abietane.}, language = {en} } @article{KunzLabesWieseetal.2014, author = {Kunz, Anna Lena and Labes, Antje and Wiese, Jutta and Bruhn, Torsten and Bringmann, Gerhard and Imhoff, Johannes F.}, title = {Nature's Lab for Derivatization: New and Revised Structures of a Variety of Streptophenazines Produced by a Sponge-Derived Streptomyces Strain}, series = {Marine Drugs}, volume = {12}, journal = {Marine Drugs}, number = {4}, issn = {1660-3397}, doi = {10.3390/md12041699}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-116816}, pages = {1699-1714}, year = {2014}, abstract = {Eight streptophenazines (A-H) have been identified so far as products of Streptomyces strain HB202, which was isolated from the sponge Halichondria panicea from the Baltic Sea. The variation of bioactivities based on small structural changes initiated further studies on new derivatives. Three new streptophenazines (I-K) were identified after fermentation in the present study. In addition, revised molecular structures of streptophenazines C, D, F and H are proposed. Streptophenazines G and K exhibited moderate antibacterial activity against the facultative pathogenic bacterium Staphylococcus epidermidis and against Bacillus subtilis. All tested compounds (streptophenazines G, I-K) also showed moderate activities against PDE 4B.}, language = {en} }