@phdthesis{Huber2020,
  author    = {Huber, Philipp},
  title     = {Megakaryocyte localization in the bone marrow depending on the knock-out of small Rho GTPases},
  doi       = {10.25972/OPUS-20051},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-200513},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2020},
  abstract  = {This work focuses on megakaryocyte physiology with a special interest in the description of the localization of megakaryocytes in the bone marrow in mice single-deficient of the small Rho GTPase RhoA or double-deficient for RhoA and Cdc42. RhoA knock-out mice revealed intraluminal presence of megakaryocytes in bone marrow sinusoids. In a next step, potential aggravation, attenuation or preservation of this phenotype was studied in related mouse strains and also in the setting of platelet depletion and blockage of important megakaryocyte and platelet glycoprotein receptors in order to understand underlying singling pathways. A second part of this thesis studied the role of RhoF in filopodia formation and scrutinized RhoF deficient mice with regard to platelet activation and degranulation.},
  subject      = {Histologie},
  language  = {en}
}