@article{SchliewenFrickeSchartletal.1993,
  author    = {Schliewen, U. and Fricke, H. and Schartl, Manfred and Epplen, J{\"o}rg T. and Paabo, S.},
  title     = {Which home for coelacanth?},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61606},
  year      = {1993},
  abstract  = {No abstract available},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@article{KruseShenArnoldetal.1993,
  author    = {Kruse, N. and Shen, B. J. and Arnold, S. and Tony, H. P. and M{\"u}ller, T. and Sebald, Walter},
  title     = {Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62451},
  year      = {1993},
  abstract  = {Interleukin 4 (IL-4) exerts a decisive role in the coord.ination of proteelive immune responses against parasites, particularly helminths. A disregulation of ll.r4 function is possibly involved in the genesis of allergic disease states. The search for important amino acid residues in human ll.r4 by mutational analysis of charged invariant amino acid positions identified two distinct functional sites in the 4-helix-bundle protein. Site 1 was marked by amino acid substitutions of the glutamic acid at position 9 in helix A and arginine at position 88 in helix C. Exchanges at both positions led to IL-4 variants deficient in binding to the extracellular domain of the ll.r4 receptor (IL-4ReJ. In parallel, up to 1000-fold increased concentrations of this type of variant were required to induce T -cell proliferation and B-eeil CD23 expression. Site 2 was marked by amino acid exchanges in helix D at positions 121, 124 and 125 (arginine, tyrosine and serine respectively in the wild-type).ß.A variants affected at site 2 exhibited partial agonist activity during T -cell proliferation; however, they still bound with high affinity to IL-4Rex. [The generation of an IL-4 antagonist by replacing tyrosine 124 with aspartic acid has been described before by Kruse et al. (1992) (EMBO }., 11, 3237-3244)]. These findings indicate that IL-4 functions by bind.ing IL-4Rex via site 1 which is constituted by residues on helices A and C. They further suggest that the association of a second, still undetined receptor protein with site 2 in helix D activates the receptor system and generates a transmembrane signal.},
  subject      = {Biochemie},
  language  = {en}
}
@article{AdamDimitrijevicSchartl1993,
  author    = {Adam, Dieter and Dimitrijevic, Nicola and Schartl, Manfred},
  title     = {Tumor suppression in Xiphophorus by an accidentally acquired promoter},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61630},
  year      = {1993},
  abstract  = {Melanoma formation in the teleost Xiphophorus is caused by a dominant genetic locus, Tu. This locus includes the Xmrk oncogene, which encodes a receptor tyrosine kinase. Tumor induction is. suppressed in wild-type fish by a tumor suppressor locus, R. Molecular genetic analyses revealed that the Tu locus emerged by nonhomologaus recombination of the Xmrk proto-oncogene with a previously uncharacterized sequence, D. This event generated an additional copy of Xmrk with a new promoter. Suppression of the new Xmrk promoter by R in parental fish and its deregulation in hybrids explain the genetics of melanoma formation in Xiphophorus.},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@misc{DandekarArgos1993,
  author    = {Dandekar, Thomas and Argos, P.},
  title     = {The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted \(\alpha\)-helices: Crystal structure of the protein DNA-complex},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-29866},
  year      = {1993},
  abstract  = {No abstract available},
  language  = {en}
}
@article{WeisenbergerScheerBenavente1993,
  author    = {Weisenberger, Dieter and Scheer, Ulrich and Benavente, Ricardo},
  title     = {The DNA topoisomerase I inhibitor camptothecin blocks postmitotic reformation of nucleoli in mammmalian cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41434},
  year      = {1993},
  abstract  = {No abstract available},
  subject      = {Cytologie},
  language  = {en}
}
@misc{ScheerThiryGoessens1993,
  author    = {Scheer, Ulrich and Thiry, Marc and Goessens, Guy},
  title     = {Structure, function and assembly of the nucleolus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-32057},
  year      = {1993},
  abstract  = {No abstract available},
  language  = {en}
}
@misc{GesslerBruns1993,
  author    = {Gessler, Manfred and Bruns, Gail A.},
  title     = {Sequence of the WT1 upstream region including the Wit-1 gene},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-30193},
  year      = {1993},
  abstract  = {No abstract available},
  language  = {en}
}
@article{HongSchartl1993,
  author    = {Hong, Yunhan and Schartl, Manfred},
  title     = {Sequence of the growth hormone (GH) gene from the silver carp (Hypophthalmichthys molitrix) and evolution of GH genes in vertebrates},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61620},
  year      = {1993},
  abstract  = {The silver carp (Hypophthalmichthys molitrix) growth hormone (GH) genewas isolated and sequenced following amplification from genomic DNA by the polymerase chain reaction. The gene spans a region of approx. 2.5 kb nucleotides (nt) and consists of five exons. The sequence predicts a polypeptide of 210 amino acids (aa) including a putative signal peptide of 22 hydrophobic aa residues. The arrangement of exons and introns is identical to the GH genes of common carp, grass carp, and very similar to mammals and birds, but quite different from that for the GH genes of tilapia and salmonids. The silver carp GH gene shares a high homology at the nt and aa Ievels with those of grass carp (95.3\% nt, 99.5\% aa) and of common carp (81\% nt, 95.7\% aa).},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@article{SchartlErbeldingDenkHolteretal.1993,
  author    = {Schartl, Manfred and Erbelding-Denk, Claudia and Holter, Sabine and Nanda, Indrajit and Schmid, Michael and Schroder, Johannes H. and Epplen, J{\"o}rg T.},
  title     = {Reproductive failure of dominant males in the poeciliid fish Limia perugiae determined by DNA fingerprinting},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61643},
  year      = {1993},
  abstract  = {Hierarchical structures among male indlviduals in a population are frequently reflected ln differences in aggressive and reproductive behavior and access to the females. In general, sodal dominance requires the Investments, which in turn then may have to be compensated for by high reproductive success. However, this hypothesls has so far only been sufficiently tested in small mating groups (one or two males with one or two females) due to the difficulties of determining paternity by conventional methods. DNA fingerprinting overcomes these problems by offering the possibility to determine genetic relationships and mating patterns within larger groups [Borke, T. (1989) Trends Ecol. Evol. 4, 139-144]. We show here that in the poecUiid fish Limia perugitu, in small matlng groups the dominant male has 8 mating success of 100\%, whereas ln larger groups lts contribution to the offspring unexpectedly drops to zero.},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@article{NandaSchartlEpplenetal.1993,
  author    = {Nanda, Indrajit and Schartl, Manfred and Epplen, J{\"o}rg T. and Feichtinger, Wolfgang and Schmid, Michael},
  title     = {Primitive sex chromosomes in poeciliid fishes harbor simple repetitive DNA sequences},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61659},
  year      = {1993},
  abstract  = {The demonstration ofthe chromosomal mode ofsex determinationvia genetic experiments as well as the absence of heteromorphic sex chromosomes affirm poeciliid fishes as a unique group among vertebrates that are endowed with the mostprimitive form of sex chromosornes. In many different taxa the evolutionary process involved in the differentiation ofadvanced sex chromosomes is outlined through sex specifically organized repetitive sequences. In this investigation hydridization of synthetic probes specific to genomic simple repeat motifs uncovers a sex-specific hybridization pattern in certain viviparaus fishes ofthe family Poeciliidae. The hybridization pattern together with specific staining ofthe constitutive heterochromatin by C-banding reveals heterogamety in males (Poecilia reticulata) as weil as in females (P. sphenops). In P. velifera, however, C-banding alone fails to unravel the heterogametic status. The female specific W-chromosome can be detected by simple repetitive sequence probes. Therefore, the principal significance of heterochromatization as a means of generating differentiated sex chromosomes is evident.},
  subject      = {Physiologische Chemie},
  language  = {en}
}