@phdthesis{Dornhaus2002,
  author    = {Dornhaus, Anna},
  title     = {The role of communication in the foraging process of social bees},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-3468},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2002},
  abstract  = {In the various groups of social bees, different systems of communication about food sources occur. These communication systems are different solutions to a common problem of social insects: efficiently allocating the necessary number of workers first to the task of foraging and second to the most profitable food sources. The solution chosen by each species depends on the particular ecological circumstances as well as the evolutionary history of that species. For example, the outstanding difference between the bumble bee and the honey bee system is that honey bees can communicate the location of profitable food sources to nestmates, which bumble bees cannot. To identify possible selection pressures that could explain this difference, I have quantified the benefits of communicating location in honey bees. I show that these strongly depend on the habitat, and that communicating location might not benefit bees in temperate habitats. This could be due to the differing spatial distributions of resources in different habitats, in particular between temperate and tropical regions. These distributions may be the reason why the mostly temperate-living bumble bees have never evolved a communication system that allows them to transfer information on location of food sources, whereas most tropical social bees (all honey bees and many stingless bees) are able to recruit nestmates to specific points in their foraging range. Nevertheless, I show that in bumble bees the allocation of workers to foraging is also regulated by communication. Successful foragers distribute in the nest a pheromone which alerts other bees to the presence of food. This pheromone stems from a tergite gland, the function of which had not been identified previously. Usage of a pheromone in the nest to alert other individuals to forage has not been described in other social insects, and might constitute a new mode of communicating about food sources. The signal might be modulated depending on the quality of the food source. Bees in the nest sample the nectar that has been brought into the nest. Their decision whether to go out and forage depends not only on the pheromone signal, but also on the quality of the nectar they have sampled. In this way, foraging activity of a bumble bee colony is adjusted to foraging conditions, which means most bees are allocated to foraging only if high-quality food sources are available. In addition, foraging activity is adjusted to the amount of food already stored. In a colony with full honeypots, no new bees are allocated to foraging. These results help us understand how the allocation of workers to the task of food collection is regulated according to external and internal nest conditions in bumble bees.},
  subject      = {Hummel},
  language  = {en}
}
@phdthesis{Barnsteiner2019,
  author    = {Barnsteiner, Stefanie},
  title     = {CCR6 kontrolliert selektiv die Monozyten-vermittelte Entz{\"u}ndungsreaktion in der Atherosklerose},
  doi       = {10.25972/OPUS-17910},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-179104},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2019},
  abstract  = {Der Chemokinrezeptor CCR6 wird von einer Vielzahl unterschiedener Zelltypen exprimiert, wie zum Beispiel Monozyten, Th17-Zellen und regulatorische T-Zellen, die im Zusammenhang mit der Entstehung von Atherosklerose stehen. Um die Bedeutung von CCR6 in der Pathogenese der Atherosklerose bestimmen zu k{\"o}nnen, wurden CCR6-defiziente (Ccr6-/- ) M{\"a}use mit low-density lipoprotein receptordefizienten (Ldlr-/-) M{\"a}usen gekreuzt, um Tiere zu erhalten, die anf{\"a}llig f{\"u}r Atherosklerose und zudem CCR6-defizient sind. Nach acht Wochen pro-atherogener, fettreicher western-type diet war die Auspr{\"a}gung der atherosklerotischen L{\"a}sionen im Aortensinus und der gesamten Aorta, sowie deren Gehalt an Plaquemakrophagen in den Ccr6-/-Ldlr-/- Tieren im Vergleich zu den Ldlr-/- Kontrolltieren signifikant vermindert. Die lokale und die systemische Verteilung von T-Zellen sowie die H{\"a}ufigkeit von Th1-, Th17-Zellen und regulatorischen T-Zellen blieb hingegen unver{\"a}ndert. Im Gegensatz dazu reduzierte sich die Zahl der im Blut zirkulierenden Gr-1high und Gr-1low Monozyten in den Ccr6-/-Ldlr-/- Tieren deutlich. Weiter konnte gezeigt werden, dass {\"u}ber CCR6 in vitro die Adh{\"a}sion von Monozyten an inflammatorisch ver{\"a}ndertem Endothel und in vivo die Adh{\"a}sion von Leukozyten an das Endothel der Karotiden vermittelt wird. Des Weiteren wurden in einem air pouch-Modell f{\"u}r akute Entz{\"u}ndungsreaktionen mittels CCR6 spezifisch Monozyten, aber keine TZellen rekrutiert. Summa summarum konnte die Bedeutung von CCR6 auf verschiedenen Ebenen der Pathogenese der Atherosklerose gezeigt werden: W{\"a}hrend CCR6 f{\"u}r die Hypercholesterin{\"a}mie assoziierte adaptive Immunantwort entbehrlich ist, reguliert es die Mobilisierung, Adh{\"a}sion und Rekrutierung von Monozyten und kontrolliert {\"u}ber diese Mechanismen die Akkumulation von Makrophagen und Genese atherosklerotischer L{\"a}sionen. CCR6 und sein Ligand CCL20 k{\"o}nnten somit vielversprechende Ziele neuer pharmakologischer Therapieans{\"a}tze sein, um auch die Atherogenese im Menschen zu unterbinden. Die Ergebnisse der Dissertation wurden im Dezember 2013 im Journal Thrombosis and Haematostasis unter dem Titel "CCR6 selectively promotes monocyte mediated inflammation and atherogenesis in mice" in geteilter Erstautorenschaft von Helga Manthey, Cl{\´e}ment Cochain und Stefanie Barnsteiner ver{\"o}ffentlicht (PMID: 24114205).},
  subject      = {Atherosklerose},
  language  = {de}
}