@article{GrobHeinigGruebeletal.2021,
  author    = {Grob, Robin and Heinig, Niklas and Gr{\"u}bel, Kornelia and R{\"o}ssler, Wolfgang and Fleischmann, Pauline N.},
  title     = {Sex-specific and caste-specific brain adaptations related to spatial orientation in Cataglyphis ants},
  series = {Journal of Comparative Neurology},
  volume    = {529},
  journal   = {Journal of Comparative Neurology},
  number    = {18},
  doi       = {10.1002/cne.25221},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-257299},
  pages     = {3882-3892},
  year      = {2021},
  abstract  = {Cataglyphis desert ants are charismatic central place foragers. After long-ranging foraging trips, individual workers navigate back to their nest relying mostly on visual cues. The reproductive caste faces other orientation challenges, i.e. mate finding and colony foundation. Here we compare brain structures involved in spatial orientation of Cataglyphis nodus males, gynes, and foragers by quantifying relative neuropil volumes associated with two visual pathways, and numbers and volumes of antennal lobe (AL) olfactory glomeruli. Furthermore, we determined absolute numbers of synaptic complexes in visual and olfactory regions of the mushroom bodies (MB) and a major relay station of the sky-compass pathway to the central complex (CX). Both female castes possess enlarged brain centers for sensory integration, learning, and memory, reflected in voluminous MBs containing about twice the numbers of synaptic complexes compared with males. Overall, male brains are smaller compared with both female castes, but the relative volumes of the optic lobes and CX are enlarged indicating the importance of visual guidance during innate behaviors. Male ALs contain greatly enlarged glomeruli, presumably involved in sex-pheromone detection. Adaptations at both the neuropil and synaptic levels clearly reflect differences in sex-specific and caste-specific demands for sensory processing and behavioral plasticity underlying spatial orientation.},
  language  = {en}
}
@article{TomeiAdamsUccellinietal.2012,
  author    = {Tomei, Sara and Adams, Sharon and Uccellini, Lorenzo and Bedognetti, Davide and De Giorgi, Valeria and Erdenebileg, Narnygerel and Libera Ascierto, Maria and Reinboth, Jennifer and Liu, Qiuzhen and Bevilacqua, Generoso and Wang, Ena and Mazzanti, Chiara and Marincola, Francesco M.},
  title     = {Association between HRAS rs12628 and rs112587690 polymorphisms with the risk of melanoma in the North American population},
  series = {Medical Oncology},
  volume    = {29},
  journal   = {Medical Oncology},
  number    = {5},
  doi       = {dx.doi.org/10.1007/s12032-012-0255-3},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-126834},
  pages     = {3456-3461},
  year      = {2012},
  abstract  = {HRAS belongs to the RAS genes superfamily. RAS genes are important players in several human tumors and the single-nucleotide polymorphism rs12628 has been shown to contribute to the risk of bladder, colon, gastrointestinal, oral, and thyroid carcinoma. We hypothesized that this SNP may affect the risk of cutaneous melanoma as well. HRAS gene contains a polymorphic region (rs112587690), a repeated hexanucleotide -GGGCCT- located in intron 1. Three alleles of this region, P1, P2, and P3, have been identified that contain two, three, and four repeats of the hexanucleotide, respectively. We investigated the clinical impact of these polymorphisms in a case-control study. A total of 141 melanoma patients and 118 healthy donors from the North America Caucasian population were screened for rs12628 and rs112587690 polymorphisms. Genotypes were assessed by capillary sequencing or fragment analysis, respectively, and rs12628 CC and rs112587690 P1P1 genotypes significantly associated with increased melanoma risk (OR = 3.83, p = 0.003; OR = 11.3, p = 0.033, respectively), while rs112587690 P1P3 frequency resulted significantly higher in the control group (OR = 0.5, p = 0.017). These results suggest that rs12628 C homozygosis may be considered a potential risk factor for melanoma development in the North American population possibly through the linkage to rs112587690.},
  language  = {en}
}