@article{HelmprobstKneitzKlotzetal.2021,
  author    = {Helmprobst, Frederik and Kneitz, Susanne and Klotz, Barbara and Naville, Magali and Dechaud, Corentin and Volff, Jean-Nicolas and Schartl, Manfred},
  title     = {Differential expression of transposable elements in the medaka melanoma model},
  series = {PLoS One},
  volume    = {16},
  journal   = {PLoS One},
  number    = {10},
  doi       = {10.1371/journal.pone.0251713},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-260615},
  year      = {2021},
  abstract  = {Malignant melanoma incidence is rising worldwide. Its treatment in an advanced state is difficult, and the prognosis of this severe disease is still very poor. One major source of these difficulties is the high rate of metastasis and increased genomic instability leading to a high mutation rate and the development of resistance against therapeutic approaches. Here we investigate as one source of genomic instability the contribution of activation of transposable elements (TEs) within the tumor. We used the well-established medaka melanoma model and RNA-sequencing to investigate the differential expression of TEs in wildtype and transgenic fish carrying melanoma. We constructed a medaka-specific TE sequence library and identified TE sequences that were specifically upregulated in tumors. Validation by qRT- PCR confirmed a specific upregulation of a LINE and an LTR element in malignant melanomas of transgenic fish.},
  language  = {en}
}
@article{DechaudVolffSchartletal.2019,
  author    = {Dechaud, Corentin and Volff, Jean-Nicolas and Schartl, Manfred and Naville, Magali},
  title     = {Sex and the TEs: transposable elements in sexual development and function in animals},
  series = {Mobile DNA},
  volume    = {10},
  journal   = {Mobile DNA},
  doi       = {10.1186/s13100-019-0185-0},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-202510},
  pages     = {42},
  year      = {2019},
  abstract  = {Transposable elements are endogenous DNA sequences able to integrate into and multiply within genomes. They constitute a major source of genetic innovations, as they can not only rearrange genomes but also spread ready-to-use regulatory sequences able to modify host gene expression, and even can give birth to new host genes. As their evolutionary success depends on their vertical transmission, transposable elements are intrinsically linked to reproduction. In organisms with sexual reproduction, this implies that transposable elements have to manifest their transpositional activity in germ cells or their progenitors. The control of sexual development and function can be very versatile, and several studies have demonstrated the implication of transposable elements in the evolution of sex. In this review, we report the functional and evolutionary relationships between transposable elements and sexual reproduction in animals. In particular, we highlight how transposable elements can influence expression of sexual development genes, and how, reciprocally, they are tightly controlled in gonads. We also review how transposable elements contribute to the organization, expression and evolution of sexual development genes and sex chromosomes. This underscores the intricate co-evolution between host functions and transposable elements, which regularly shift from a parasitic to a domesticated status useful to the host.},
  language  = {en}
}