@article{LawitschkaBrunmairBaueretal.2021,
  author    = {Lawitschka, Anita and Brunmair, Matthias and Bauer, Dorothea and Zubarovskaya, Natalia and Felder-Puig, Rosemarie and Strahm, Brigitte and Bader, Peter and Strauss, Gabriele and Albert, Michael and Luettichau, Irene von and Greinix, Hildegard and Wolff, Daniel and Peters, Christina},
  title     = {Psychometric properties of the Activities Scale for Kids-performance after allogeneic hematopoietic stem cell transplantation in adolescents and children},
  series = {Wiener klinische Wochenschrift},
  volume    = {133},
  journal   = {Wiener klinische Wochenschrift},
  number    = {1-2},
  doi       = {10.1007/s00508-020-01641-w},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-281100},
  pages     = {41-51},
  year      = {2021},
  abstract  = {Background The psychometric properties of an instrument, the Activity Scale for Kids-performance (ASKp), were assessed which was proposed to capture physical functioning after allogeneic hematopoietic stem cell transplantation (HSCT). Additionally, this multicenter observational prospective study investigated the influence of clinical correlates focusing on chronic graft-versus-host disease (cGVHD). Methods Patient-reported ASKp, clinician-reported Karnofsky/Lansky status (KPS/PSS), patient characteristics and cGVHD details were assessed of 55 patients with a median age of 12 years at baseline after day +100 post-HSCT and every 3 months during the next 18 months. The psychometric properties were evaluated and ASKp and KPS/PSS status was compared using ANOVAS and multiple regression models. Results The German version of the ASKp showed good psychometric properties except for ceiling effects. Discrimination ability of the ASKp was good regarding the need for devices but failed to predict cGVHD patients. Both the ASKp and the KPS/PSS were associated with patients after adoptive cell therapy being in need for devices, suffering from overlap cGVHD and from steroid side effects but not with patients' age and gender. In contrast to the KPS/PSS the ASKp only showed significant differences after merging moderate and severe cGHVD patients when comparing them to No-cGVHD (F = 4.050; p = 0.049), being outperformed by the KPS/PSS (F = 20.082; p < 0.001). Conclusion The ASKp showed no clear advantages compared to KPS/PSS even though economical and patients' effort was higher. Further application range may be limited through ceiling effects. Both should be taken into consideration. Therefore, the results may not support the usage of ASKp after HSCT and rather suggest KPS/PSS, both patient and clinician reported.},
  language  = {en}
}
@article{WajantBeilhack2019,
  author    = {Wajant, Harald and Beilhack, Andreas},
  title     = {Targeting regulatory T cells by addressing tumor necrosis factor and its receptors in allogeneic hematopoietic cell transplantation and cancer},
  series = {Frontiers in Immunology},
  volume    = {10},
  journal   = {Frontiers in Immunology},
  number    = {2040},
  doi       = {10.3389/fimmu.2019.02040},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-201578},
  year      = {2019},
  abstract  = {An intricate network of molecular and cellular actors orchestrates the delicate balance between effector immune responses and immune tolerance. The pleiotropic cytokine tumor necrosis factor-alpha (TNF) proves as a pivotal protagonist promoting but also suppressing immune responses. These opposite actions are accomplished through specialist cell types responding to TNF via TNF receptors TNFR1 and TNFR2. Recent findings highlight the importance of TNFR2 as a key regulator of activated natural FoxP3+ regulatory T cells (Tregs) in inflammatory conditions, such as acute graft-vs.-host disease (GvHD) and the tumor microenvironment. Here we review recent advances in our understanding of TNFR2 signaling in T cells and discuss how these can reconcile seemingly conflicting observations when manipulating TNF and TNFRs. As TNFR2 emerges as a new and attractive target we furthermore pinpoint strategies and potential pitfalls for therapeutic targeting of TNFR2 for cancer treatment and immune tolerance after allogeneic hematopoietic cell transplantation.},
  language  = {en}
}
@article{FujiKappEinsele2013,
  author    = {Fuji, Shigeo and Kapp, Markus and Einsele, Hermann},
  title     = {Alloreactivity of virus-specific T cells: possible implication of graft-versus-host disease and graft-versus-leukemia effects},
  series = {Frontiers in Immunology},
  volume    = {4},
  journal   = {Frontiers in Immunology},
  number    = {330},
  doi       = {10.3389/fimmu.2013.00330},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-129260},
  year      = {2013},
  abstract  = {Immune reconstitution of functional virus-specific T cells after allogeneic hematopoietic stem cell transplantation (HSCT) has been intensively investigated. However, the possible role of crossreactivity of these virus-specific T cells against allogeneic targets is still unclear. Theoretically, as in the field of organ transplantation, virus-specific T cells possess crossreactivity potential after allogeneic HSCT. Such crossreactivity is assumed to play a role in graft-versus-host disease and graft-versus-leukemia effects. In this article, we aim to give a comprehensive overview of current understanding about crossreactivity of virus-specific T cells.},
  language  = {en}
}
@article{FujKappEinsele2014,
  author    = {Fuj, Shigeo and Kapp, Markus and Einsele, Hermann},
  title     = {Possible Implication of Bacterial Infection in Acute Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation},
  series = {Frontiers in Oncology},
  volume    = {4},
  journal   = {Frontiers in Oncology},
  number    = {89},
  issn      = {2234-943X},
  doi       = {10.3389/fonc.2014.00089},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-120674},
  year      = {2014},
  abstract  = {Graft-versus-host disease (GVHD) is still one of the major causes of morbidity and mortality in allogeneic hematopoietic stem cell transplantation (HSCT). In the pathogenesis of acute GVHD, it has been established that donor-derived T-cells activated in the recipient play a major role in GVHD in initiation and maintenance within an inflammatory cascade. To reduce the risk of GVHD, intensification of GVHD prophylaxis like T-cell depletion is effective, but it inevitably increases the risk of infectious diseases and abrogates beneficial graft-versus-leukemia effects. Although various cytokines are considered to play an important role in the pathogenesis of GVHD, GVHD initiation is such a complex process that cannot be prevented by means of single inflammatory cytokine inhibition. Thus, efficient methods to control the whole inflammatory milieu both on cellular and humoral view are needed. In this context, infectious diseases can theoretically contribute to an elevation of inflammatory cytokines after allogeneic HSCT and activation of various subtypes of immune effector cells, which might in summary lead to an aggravation of acute GVHD. The appropriate treatments or prophylaxis of bacterial infection during the early phase after allogeneic HSCT might be beneficial to reduce not only infectious-related but also GVHD-related mortality. Here, we aim to review the literature addressing the interactions of bacterial infections and GVHD after allogeneic HSCT.},
  language  = {en}
}